Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy

Patients with Waldenström macroglobulinaemia (WM) are at increased risk of severe COVID‐19 infection and have poor immune responses to COVID‐19 vaccination. This study assessed whether a closely monitored pause in Bruton's Tyrosine Kinase inhibitor (BTKi) therapy might result in an improved hum...

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Autores principales: Rankin, Katherine, Hastak, Priyanka, Wong, Alexander, Sasson, Sarah C., Beaton, Brendan, Yeola, Avani, Warden, Andrew, Turville, Stuart, Kelleher, Anthony D., Brilot, Fabienne, Trotman, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435711/
https://www.ncbi.nlm.nih.gov/pubmed/37601863
http://dx.doi.org/10.1002/jha2.724
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author Rankin, Katherine
Hastak, Priyanka
Wong, Alexander
Sasson, Sarah C.
Beaton, Brendan
Yeola, Avani
Warden, Andrew
Turville, Stuart
Kelleher, Anthony D.
Brilot, Fabienne
Trotman, Judith
author_facet Rankin, Katherine
Hastak, Priyanka
Wong, Alexander
Sasson, Sarah C.
Beaton, Brendan
Yeola, Avani
Warden, Andrew
Turville, Stuart
Kelleher, Anthony D.
Brilot, Fabienne
Trotman, Judith
author_sort Rankin, Katherine
collection PubMed
description Patients with Waldenström macroglobulinaemia (WM) are at increased risk of severe COVID‐19 infection and have poor immune responses to COVID‐19 vaccination. This study assessed whether a closely monitored pause in Bruton's Tyrosine Kinase inhibitor (BTKi) therapy might result in an improved humoral response to a 3rd COVID‐19 vaccine dose. Improved response was observed in WM patients who paused their BTKi, compared to a group who did not pause their BTKi. However, the response was attenuated after BTKi recommencement. This data contributes to our understanding of vaccination strategies in this patient group and may help inform consensus approaches in the future.
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spelling pubmed-104357112023-08-19 Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy Rankin, Katherine Hastak, Priyanka Wong, Alexander Sasson, Sarah C. Beaton, Brendan Yeola, Avani Warden, Andrew Turville, Stuart Kelleher, Anthony D. Brilot, Fabienne Trotman, Judith EJHaem Short Reports Patients with Waldenström macroglobulinaemia (WM) are at increased risk of severe COVID‐19 infection and have poor immune responses to COVID‐19 vaccination. This study assessed whether a closely monitored pause in Bruton's Tyrosine Kinase inhibitor (BTKi) therapy might result in an improved humoral response to a 3rd COVID‐19 vaccine dose. Improved response was observed in WM patients who paused their BTKi, compared to a group who did not pause their BTKi. However, the response was attenuated after BTKi recommencement. This data contributes to our understanding of vaccination strategies in this patient group and may help inform consensus approaches in the future. John Wiley and Sons Inc. 2023-06-21 /pmc/articles/PMC10435711/ /pubmed/37601863 http://dx.doi.org/10.1002/jha2.724 Text en © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Rankin, Katherine
Hastak, Priyanka
Wong, Alexander
Sasson, Sarah C.
Beaton, Brendan
Yeola, Avani
Warden, Andrew
Turville, Stuart
Kelleher, Anthony D.
Brilot, Fabienne
Trotman, Judith
Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy
title Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy
title_full Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy
title_fullStr Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy
title_full_unstemmed Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy
title_short Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy
title_sort immune response to covid‐19 vaccination in patients with waldenström macroglobulinaemia who pause their btki therapy
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435711/
https://www.ncbi.nlm.nih.gov/pubmed/37601863
http://dx.doi.org/10.1002/jha2.724
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