Monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with KMT2A rearrangement

Acute leukemia with KMT2A rearrangement shows a spectrum of immunophenotypic presentation, but blastic plasmacytoid dendritic cell differentiation is extremely rare. Here we present a case of KMT2A rearranged acute leukemia with a hybrid immunophenotype in which a single blast population showed both...

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Detalles Bibliográficos
Autores principales: Xue, Owen, Curry, Choladda V., Fang, Hong, Bueso‐Ramos, Carlos E., Medeiros, L. Jeffrey, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435717/
https://www.ncbi.nlm.nih.gov/pubmed/37601865
http://dx.doi.org/10.1002/jha2.753
Descripción
Sumario:Acute leukemia with KMT2A rearrangement shows a spectrum of immunophenotypic presentation, but blastic plasmacytoid dendritic cell differentiation is extremely rare. Here we present a case of KMT2A rearranged acute leukemia with a hybrid immunophenotype in which a single blast population showed both blastic plasmacytoid dendritic cell and monocytic differentiation. This unusual case contributes to the diversity of the immunophenotypic spectrum in KMT2A rearranged acute leukemia and also sheds light on the cell of origin of plasmacytoid dendritic cells.

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