Monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with KMT2A rearrangement

Acute leukemia with KMT2A rearrangement shows a spectrum of immunophenotypic presentation, but blastic plasmacytoid dendritic cell differentiation is extremely rare. Here we present a case of KMT2A rearranged acute leukemia with a hybrid immunophenotype in which a single blast population showed both...

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Detalles Bibliográficos
Autores principales: Xue, Owen, Curry, Choladda V., Fang, Hong, Bueso‐Ramos, Carlos E., Medeiros, L. Jeffrey, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435717/
https://www.ncbi.nlm.nih.gov/pubmed/37601865
http://dx.doi.org/10.1002/jha2.753
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author Xue, Owen
Curry, Choladda V.
Fang, Hong
Bueso‐Ramos, Carlos E.
Medeiros, L. Jeffrey
Wang, Wei
author_facet Xue, Owen
Curry, Choladda V.
Fang, Hong
Bueso‐Ramos, Carlos E.
Medeiros, L. Jeffrey
Wang, Wei
author_sort Xue, Owen
collection PubMed
description Acute leukemia with KMT2A rearrangement shows a spectrum of immunophenotypic presentation, but blastic plasmacytoid dendritic cell differentiation is extremely rare. Here we present a case of KMT2A rearranged acute leukemia with a hybrid immunophenotype in which a single blast population showed both blastic plasmacytoid dendritic cell and monocytic differentiation. This unusual case contributes to the diversity of the immunophenotypic spectrum in KMT2A rearranged acute leukemia and also sheds light on the cell of origin of plasmacytoid dendritic cells.
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spelling pubmed-104357172023-08-19 Monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with KMT2A rearrangement Xue, Owen Curry, Choladda V. Fang, Hong Bueso‐Ramos, Carlos E. Medeiros, L. Jeffrey Wang, Wei EJHaem Case Reports Acute leukemia with KMT2A rearrangement shows a spectrum of immunophenotypic presentation, but blastic plasmacytoid dendritic cell differentiation is extremely rare. Here we present a case of KMT2A rearranged acute leukemia with a hybrid immunophenotype in which a single blast population showed both blastic plasmacytoid dendritic cell and monocytic differentiation. This unusual case contributes to the diversity of the immunophenotypic spectrum in KMT2A rearranged acute leukemia and also sheds light on the cell of origin of plasmacytoid dendritic cells. John Wiley and Sons Inc. 2023-07-03 /pmc/articles/PMC10435717/ /pubmed/37601865 http://dx.doi.org/10.1002/jha2.753 Text en © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Xue, Owen
Curry, Choladda V.
Fang, Hong
Bueso‐Ramos, Carlos E.
Medeiros, L. Jeffrey
Wang, Wei
Monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with KMT2A rearrangement
title Monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with KMT2A rearrangement
title_full Monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with KMT2A rearrangement
title_fullStr Monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with KMT2A rearrangement
title_full_unstemmed Monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with KMT2A rearrangement
title_short Monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with KMT2A rearrangement
title_sort monocytic and blastic plasmacytoid dendritic cell differentiation in acute leukemia with kmt2a rearrangement
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435717/
https://www.ncbi.nlm.nih.gov/pubmed/37601865
http://dx.doi.org/10.1002/jha2.753
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