HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma

Viral cell‐free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus‐associated tumors. We investigated whether the amount of cfDNA of human T‐cell leukemia virus type 1 (HTLV‐1) correlates with disease state in adult T‐cell leukemia‐lymphoma (ATL). HT...

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Autores principales: Katsuya, Hiroo, Nakamura, Hideaki, Maeda, Aya, Ishii, Keitaro, Nagaie, Toshiaki, Sano, Haruhiko, Sano, Haruna, Itamura, Hidekazu, Okamoto, Sho, Ando, Toshihiko, Watanabe, Toshiki, Uchimaru, Kaoru, Satou, Yorifumi, Sueoka, Eisaburo, Kimura, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435724/
https://www.ncbi.nlm.nih.gov/pubmed/37601876
http://dx.doi.org/10.1002/jha2.725
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author Katsuya, Hiroo
Nakamura, Hideaki
Maeda, Aya
Ishii, Keitaro
Nagaie, Toshiaki
Sano, Haruhiko
Sano, Haruna
Itamura, Hidekazu
Okamoto, Sho
Ando, Toshihiko
Watanabe, Toshiki
Uchimaru, Kaoru
Satou, Yorifumi
Sueoka, Eisaburo
Kimura, Shinya
author_facet Katsuya, Hiroo
Nakamura, Hideaki
Maeda, Aya
Ishii, Keitaro
Nagaie, Toshiaki
Sano, Haruhiko
Sano, Haruna
Itamura, Hidekazu
Okamoto, Sho
Ando, Toshihiko
Watanabe, Toshiki
Uchimaru, Kaoru
Satou, Yorifumi
Sueoka, Eisaburo
Kimura, Shinya
author_sort Katsuya, Hiroo
collection PubMed
description Viral cell‐free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus‐associated tumors. We investigated whether the amount of cfDNA of human T‐cell leukemia virus type 1 (HTLV‐1) correlates with disease state in adult T‐cell leukemia‐lymphoma (ATL). HTLV‐1 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV‐1 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV‐1 cfDNA can be a universal biomarker that reflects the expansion of ATL clones.
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spelling pubmed-104357242023-08-19 HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma Katsuya, Hiroo Nakamura, Hideaki Maeda, Aya Ishii, Keitaro Nagaie, Toshiaki Sano, Haruhiko Sano, Haruna Itamura, Hidekazu Okamoto, Sho Ando, Toshihiko Watanabe, Toshiki Uchimaru, Kaoru Satou, Yorifumi Sueoka, Eisaburo Kimura, Shinya EJHaem Short Reports Viral cell‐free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus‐associated tumors. We investigated whether the amount of cfDNA of human T‐cell leukemia virus type 1 (HTLV‐1) correlates with disease state in adult T‐cell leukemia‐lymphoma (ATL). HTLV‐1 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV‐1 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV‐1 cfDNA can be a universal biomarker that reflects the expansion of ATL clones. John Wiley and Sons Inc. 2023-05-26 /pmc/articles/PMC10435724/ /pubmed/37601876 http://dx.doi.org/10.1002/jha2.725 Text en © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Katsuya, Hiroo
Nakamura, Hideaki
Maeda, Aya
Ishii, Keitaro
Nagaie, Toshiaki
Sano, Haruhiko
Sano, Haruna
Itamura, Hidekazu
Okamoto, Sho
Ando, Toshihiko
Watanabe, Toshiki
Uchimaru, Kaoru
Satou, Yorifumi
Sueoka, Eisaburo
Kimura, Shinya
HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma
title HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma
title_full HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma
title_fullStr HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma
title_full_unstemmed HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma
title_short HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma
title_sort htlv‐1 cell‐free dna in plasma as a potential biomarker in htlv‐1 carriers and adult t‐cell leukemia‐lymphoma
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435724/
https://www.ncbi.nlm.nih.gov/pubmed/37601876
http://dx.doi.org/10.1002/jha2.725
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