Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications

Neutrophil extracellular traps (NETs) are known as extracellular fibers networks consisting of antimicrobial proteins and decondensated chromatin DNA released by activated neutrophils. NETosis is a NETs-induced neutrophilic cell death which is unique from necrosis or apoptosis. Besides its neutraliz...

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Autores principales: Zhu, Yuyan, Xia, Xuan, He, Qian, Xiao, Qing-Ao, Wang, Decheng, Huang, Meirong, Zhang, Xiaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435749/
https://www.ncbi.nlm.nih.gov/pubmed/37600700
http://dx.doi.org/10.3389/fendo.2023.1202463
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author Zhu, Yuyan
Xia, Xuan
He, Qian
Xiao, Qing-Ao
Wang, Decheng
Huang, Meirong
Zhang, Xiaolin
author_facet Zhu, Yuyan
Xia, Xuan
He, Qian
Xiao, Qing-Ao
Wang, Decheng
Huang, Meirong
Zhang, Xiaolin
author_sort Zhu, Yuyan
collection PubMed
description Neutrophil extracellular traps (NETs) are known as extracellular fibers networks consisting of antimicrobial proteins and decondensated chromatin DNA released by activated neutrophils. NETosis is a NETs-induced neutrophilic cell death which is unique from necrosis or apoptosis. Besides its neutralizing pathogen, NETosis plays a crucial role in diabetes and diabetes-related complications. In patients with diabetes, NETs-releasing products are significantly elevated in blood, and these findings confirm the association of NETosis and diabetic complications, including diabetic wound healing, diabetic retinopathy, and atherosclerosis. This article briefly summarizes the mechanisms of NETosis and discusses its contribution to the pathogenesis of diabetes-related complications and suggests new therapeutic targets by some small molecule compounds.
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spelling pubmed-104357492023-08-19 Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications Zhu, Yuyan Xia, Xuan He, Qian Xiao, Qing-Ao Wang, Decheng Huang, Meirong Zhang, Xiaolin Front Endocrinol (Lausanne) Endocrinology Neutrophil extracellular traps (NETs) are known as extracellular fibers networks consisting of antimicrobial proteins and decondensated chromatin DNA released by activated neutrophils. NETosis is a NETs-induced neutrophilic cell death which is unique from necrosis or apoptosis. Besides its neutralizing pathogen, NETosis plays a crucial role in diabetes and diabetes-related complications. In patients with diabetes, NETs-releasing products are significantly elevated in blood, and these findings confirm the association of NETosis and diabetic complications, including diabetic wound healing, diabetic retinopathy, and atherosclerosis. This article briefly summarizes the mechanisms of NETosis and discusses its contribution to the pathogenesis of diabetes-related complications and suggests new therapeutic targets by some small molecule compounds. Frontiers Media S.A. 2023-08-03 /pmc/articles/PMC10435749/ /pubmed/37600700 http://dx.doi.org/10.3389/fendo.2023.1202463 Text en Copyright © 2023 Zhu, Xia, He, Xiao, Wang, Huang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhu, Yuyan
Xia, Xuan
He, Qian
Xiao, Qing-Ao
Wang, Decheng
Huang, Meirong
Zhang, Xiaolin
Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications
title Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications
title_full Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications
title_fullStr Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications
title_full_unstemmed Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications
title_short Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications
title_sort diabetes-associated neutrophil netosis: pathogenesis and interventional target of diabetic complications
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435749/
https://www.ncbi.nlm.nih.gov/pubmed/37600700
http://dx.doi.org/10.3389/fendo.2023.1202463
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