Berberine influences multiple diseases by modifying gut microbiota

Berberine (BBR) is an isoquinoline alkaloid that is widely distributed in the plant kingdom and is commonly found in Coptis chinensis Franch. It has low bioavailability, but it can interact with gut microbiota and affect a variety of diseases. The effects of BBR in diabetes, hyperlipidemia, atherosc...

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Autores principales: Yang, Fujie, Gao, Rongmao, Luo, Xiaoxiu, Liu, Rongan, Xiong, Daqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Nutrition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435753/
https://www.ncbi.nlm.nih.gov/pubmed/37599699
http://dx.doi.org/10.3389/fnut.2023.1187718
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author Yang, Fujie
Gao, Rongmao
Luo, Xiaoxiu
Liu, Rongan
Xiong, Daqian
author_facet Yang, Fujie
Gao, Rongmao
Luo, Xiaoxiu
Liu, Rongan
Xiong, Daqian
author_sort Yang, Fujie
collection PubMed
description Berberine (BBR) is an isoquinoline alkaloid that is widely distributed in the plant kingdom and is commonly found in Coptis chinensis Franch. It has low bioavailability, but it can interact with gut microbiota and affect a variety of diseases. The effects of BBR in diabetes, hyperlipidemia, atherosclerosis, liver diseases, intestinal diseases, mental disorders, autoimmune diseases, and other diseases are all thought to be related to gut microbiota. This review systematically and comprehensively summarize these interactions and their effects, and describes the changes of gut microbiota after the intervention of different doses of berberine and its potential clinical consequences, in order to provide a basis for the rational application of BBR in the future clinical treatment.
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spelling pubmed-104357532023-08-19 Berberine influences multiple diseases by modifying gut microbiota Yang, Fujie Gao, Rongmao Luo, Xiaoxiu Liu, Rongan Xiong, Daqian Front Nutr Nutrition Berberine (BBR) is an isoquinoline alkaloid that is widely distributed in the plant kingdom and is commonly found in Coptis chinensis Franch. It has low bioavailability, but it can interact with gut microbiota and affect a variety of diseases. The effects of BBR in diabetes, hyperlipidemia, atherosclerosis, liver diseases, intestinal diseases, mental disorders, autoimmune diseases, and other diseases are all thought to be related to gut microbiota. This review systematically and comprehensively summarize these interactions and their effects, and describes the changes of gut microbiota after the intervention of different doses of berberine and its potential clinical consequences, in order to provide a basis for the rational application of BBR in the future clinical treatment. Frontiers Media S.A. 2023-08-03 /pmc/articles/PMC10435753/ /pubmed/37599699 http://dx.doi.org/10.3389/fnut.2023.1187718 Text en Copyright © 2023 Yang, Gao, Luo, Liu and Xiong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Yang, Fujie
Gao, Rongmao
Luo, Xiaoxiu
Liu, Rongan
Xiong, Daqian
Berberine influences multiple diseases by modifying gut microbiota
title Berberine influences multiple diseases by modifying gut microbiota
title_full Berberine influences multiple diseases by modifying gut microbiota
title_fullStr Berberine influences multiple diseases by modifying gut microbiota
title_full_unstemmed Berberine influences multiple diseases by modifying gut microbiota
title_short Berberine influences multiple diseases by modifying gut microbiota
title_sort berberine influences multiple diseases by modifying gut microbiota
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435753/
https://www.ncbi.nlm.nih.gov/pubmed/37599699
http://dx.doi.org/10.3389/fnut.2023.1187718
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AT luoxiaoxiu berberineinfluencesmultiplediseasesbymodifyinggutmicrobiota
AT liurongan berberineinfluencesmultiplediseasesbymodifyinggutmicrobiota
AT xiongdaqian berberineinfluencesmultiplediseasesbymodifyinggutmicrobiota

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