Cargando…

Development of an immunoassay for the simultaneous detection of GADA and ZnT8A in autoimmune diabetes using a ZnT8/GAD65 chimeric molecule

INTRODUCTION: The combined presence of autoantibodies to the 65 kDa isoform of glutamic acid decarboxylase (GADA) and to the islet-specific cation efflux transporter ZnT8 (ZnT8A) in serum is the best predictive sign of the loss of immune tolerance and the clinical manifestation of autoimmune diabete...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trabucchi, Aldana, Bombicino, Silvina Sonia, Sabljic, Adriana Victoria, Marfía, Juan Ignacio, Targovnik, Alexandra Marisa, Iacono, Rubén Francisco, Miranda, María Victoria, Valdez, Silvina Noemí
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435855/ https://www.ncbi.nlm.nih.gov/pubmed/37600804 http://dx.doi.org/10.3389/fimmu.2023.1219857

Ejemplares similares

Prokaryotic expression and characterization of the heterodimeric construction of ZnT8 and its application for autoantibodies detection in diabetes mellitus
por: Faccinetti, Natalia I., et al.
Publicado: (2017)

Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients
por: Skärstrand, H, et al.
Publicado: (2015)

Expression of recombinant glutamic acid decarboxylase in insect larvae and its application in an immunoassay for the diagnosis of autoimmune diabetes mellitus
por: Trabucchi, Aldana, et al.
Publicado: (2019)

ZnT8 Haploinsufficiency Impacts MIN6 Cell Zinc Content and β-Cell Phenotype via ZIP-ZnT8 Coregulation
por: Lawson, Rebecca, et al.
Publicado: (2019)

Genetic, Functional, and Immunological Study of ZnT8 in Diabetes
por: Huang, Qiong, et al.
Publicado: (2019)

Novel Flow Cytometric Immunoassay for Detection of Proinsulin Autoantibodies in Diabetes Mellitus Employing a Recombinant Autoantigen Expressed in E. coli
por: Sabljic, Adriana Victoria, et al.
Publicado: (2021)

Insights into the Dynamics of the Human Zinc Transporter ZnT8 by MD Simulations
por: Sala, Davide, et al.
Publicado: (2021)

Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway
por: Fujimoto, Shigeyuki, et al.
Publicado: (2013)

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
por: Dwivedi, Om Prakash, et al.
Publicado: (2019)

Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases
por: Howson, J. M. M., et al.
Publicado: (2012)

Association of Zinc Transporter-8 Autoantibody (ZnT8A) with Type 1 Diabetes Mellitus
por: Bhatty, Afreen, et al.
Publicado: (2020)

Angiotensin II Requires Zinc and Downregulation of the Zinc Transporters ZnT3 and ZnT10 to Induce Senescence of Vascular Smooth Muscle Cells
por: Patrushev, Nikolay, et al.
Publicado: (2012)

Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease
por: Zhang, Xiuli, et al.
Publicado: (2020)

Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations
por: Xue, Jing, et al.
Publicado: (2020)

The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis
por: Winslow, James W.W., et al.
Publicado: (2020)

SAT064 Establishment And Initial Characterization Of Two Parallel Targeted Human ZnT8 Knock-in Murine Lines For Studying The Type 2 Diabetes Risk Variant At SNP rs13266634 Of The ZnT8 Gene
por: Wang, Janice C, et al.
Publicado: (2023)

Altered Expression of ZnT10 in Alzheimer's Disease Brain
por: Bosomworth, Helen J., et al.
Publicado: (2013)

The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective
por: Kimura, Tomoki, et al.
Publicado: (2016)

Neuroprotective Effect of ZnT3 Knockout on Subarachnoid Hemorrhage
por: Chen, Duo, et al.
Publicado: (2018)

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells
por: Gerber, Philipp A., et al.
Publicado: (2014)

ZnT8 Is a Major CD8(+) T Cell–Recognized Autoantigen in Pediatric Type 1 Diabetes
por: Énée, Émmanuelle, et al.
Publicado: (2012)

Evaluation of the roles of the cytosolic N-terminus and His-rich loop of ZNT proteins using ZNT2 and ZNT3 chimeric mutants
por: Fukue, Kazuhisa, et al.
Publicado: (2018)

Novel bridge multi-species ELISA for detection of SARS-CoV-2 antibodies
por: Trabucchi, Aldana, et al.
Publicado: (2022)

Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 Diabetes
por: Elmaoğulları, Selin, et al.
Publicado: (2018)

Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death
por: Karsai, Maria, et al.
Publicado: (2022)

Zinc transporter 8 (ZnT8) autoantibody prevalence in black South African participants with type 1 diabetes
por: Bhola, Sureka, et al.
Publicado: (2021)

ODP562 ZnT5 Involvement in EMT in Breast Cancer
por: Miki, Yasuhiro, et al.
Publicado: (2022)

Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison’s disease
por: Fichna, Marta, et al.
Publicado: (2016)

The C‐terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant
por: Parsons, Douglas S., et al.
Publicado: (2018)

Probing the Structure and Function of the Cytosolic Domain of the Human Zinc Transporter ZnT8 with Nickel(II) Ions
por: Catapano, Maria Carmen, et al.
Publicado: (2021)

High-affinity ZnT8 Autoantibodies by Electrochemiluminescence Assay Improve Risk Prediction for Type 1 Diabetes
por: Jia, Xiaofan, et al.
Publicado: (2021)

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance
por: Mitchell, Ryan K., et al.
Publicado: (2016)

Zinc Transporter 8 (ZnT8) Expression Is Reduced by Ischemic Insults: A Potential Therapeutic Target to Prevent Ischemic Retinopathy
por: DeNiro, Michael, et al.
Publicado: (2012)

Structure/Function Analysis of human ZnT8 (SLC30A8): A Diabetes Risk Factor and Zinc Transporter
por: Daniels, Mark J., et al.
Publicado: (2020)

ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions
por: Nayak, Deepak K., et al.
Publicado: (2014)

Clinical Utility and Outcome Prediction of Early ZnT8-IgG Testing and Titer in Type 1 Diabetes
por: Dahl, Amanda R., et al.
Publicado: (2023)

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells
por: Bin, Bum-Ho, et al.
Publicado: (2018)

MiR-411 suppresses the development of bladder cancer by regulating ZnT1
por: Liu, Yang, et al.
Publicado: (2018)

Regulation of the Metal Transporters ZIP14 and ZnT10 by Manganese Intake in Mice
por: Felber, Danielle M., et al.
Publicado: (2019)

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia
por: Solomou, Antonia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gddeesk736p03tfihijo4ctnio