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Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales

Among carbapenem-resistant Enterobacterales, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of infections involving these strains, little to no cl...

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Autores principales: Merad, Yanis, Conrad, Anne, Brosset, Sophie, Schmidt, Axel, Hanriat, Camille, Lustig, Sebastien, Laurent, Frederic, Kolenda, Camille, Roussel-Gaillard, Tiphaine, Batailler, Cecile, Ferry, Tristan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435880/
https://www.ncbi.nlm.nih.gov/pubmed/37601796
http://dx.doi.org/10.3389/fmed.2023.1224922
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author Merad, Yanis
Conrad, Anne
Brosset, Sophie
Schmidt, Axel
Hanriat, Camille
Lustig, Sebastien
Laurent, Frederic
Kolenda, Camille
Roussel-Gaillard, Tiphaine
Batailler, Cecile
Ferry, Tristan
author_facet Merad, Yanis
Conrad, Anne
Brosset, Sophie
Schmidt, Axel
Hanriat, Camille
Lustig, Sebastien
Laurent, Frederic
Kolenda, Camille
Roussel-Gaillard, Tiphaine
Batailler, Cecile
Ferry, Tristan
author_sort Merad, Yanis
collection PubMed
description Among carbapenem-resistant Enterobacterales, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of infections involving these strains, little to no clinical data support the use of this association for the treatment of bone and joint infections. We report two cases of complex bone and joint infections involving metallo-beta-lactamase-producing Enterobacterales, successfully treated at our referral center with aztreonam and ceftazidime-avibactam for 12 weeks in continuous infusions through elastomeric infusors.
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spelling pubmed-104358802023-08-19 Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales Merad, Yanis Conrad, Anne Brosset, Sophie Schmidt, Axel Hanriat, Camille Lustig, Sebastien Laurent, Frederic Kolenda, Camille Roussel-Gaillard, Tiphaine Batailler, Cecile Ferry, Tristan Front Med (Lausanne) Medicine Among carbapenem-resistant Enterobacterales, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of infections involving these strains, little to no clinical data support the use of this association for the treatment of bone and joint infections. We report two cases of complex bone and joint infections involving metallo-beta-lactamase-producing Enterobacterales, successfully treated at our referral center with aztreonam and ceftazidime-avibactam for 12 weeks in continuous infusions through elastomeric infusors. Frontiers Media S.A. 2023-08-03 /pmc/articles/PMC10435880/ /pubmed/37601796 http://dx.doi.org/10.3389/fmed.2023.1224922 Text en Copyright © 2023 Merad, Conrad, Brosset, Schmidt, Hanriat, Lustig, Laurent, Kolenda, Roussel-Gaillard, Batailler, Ferry and Lyon BJI Study group. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Merad, Yanis
Conrad, Anne
Brosset, Sophie
Schmidt, Axel
Hanriat, Camille
Lustig, Sebastien
Laurent, Frederic
Kolenda, Camille
Roussel-Gaillard, Tiphaine
Batailler, Cecile
Ferry, Tristan
Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
title Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
title_full Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
title_fullStr Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
title_full_unstemmed Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
title_short Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
title_sort case report: continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing enterobacterales
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435880/
https://www.ncbi.nlm.nih.gov/pubmed/37601796
http://dx.doi.org/10.3389/fmed.2023.1224922
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