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Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
Among carbapenem-resistant Enterobacterales, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of infections involving these strains, little to no cl...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435880/ https://www.ncbi.nlm.nih.gov/pubmed/37601796 http://dx.doi.org/10.3389/fmed.2023.1224922 |
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author | Merad, Yanis Conrad, Anne Brosset, Sophie Schmidt, Axel Hanriat, Camille Lustig, Sebastien Laurent, Frederic Kolenda, Camille Roussel-Gaillard, Tiphaine Batailler, Cecile Ferry, Tristan |
author_facet | Merad, Yanis Conrad, Anne Brosset, Sophie Schmidt, Axel Hanriat, Camille Lustig, Sebastien Laurent, Frederic Kolenda, Camille Roussel-Gaillard, Tiphaine Batailler, Cecile Ferry, Tristan |
author_sort | Merad, Yanis |
collection | PubMed |
description | Among carbapenem-resistant Enterobacterales, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of infections involving these strains, little to no clinical data support the use of this association for the treatment of bone and joint infections. We report two cases of complex bone and joint infections involving metallo-beta-lactamase-producing Enterobacterales, successfully treated at our referral center with aztreonam and ceftazidime-avibactam for 12 weeks in continuous infusions through elastomeric infusors. |
format | Online Article Text |
id | pubmed-10435880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104358802023-08-19 Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales Merad, Yanis Conrad, Anne Brosset, Sophie Schmidt, Axel Hanriat, Camille Lustig, Sebastien Laurent, Frederic Kolenda, Camille Roussel-Gaillard, Tiphaine Batailler, Cecile Ferry, Tristan Front Med (Lausanne) Medicine Among carbapenem-resistant Enterobacterales, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of infections involving these strains, little to no clinical data support the use of this association for the treatment of bone and joint infections. We report two cases of complex bone and joint infections involving metallo-beta-lactamase-producing Enterobacterales, successfully treated at our referral center with aztreonam and ceftazidime-avibactam for 12 weeks in continuous infusions through elastomeric infusors. Frontiers Media S.A. 2023-08-03 /pmc/articles/PMC10435880/ /pubmed/37601796 http://dx.doi.org/10.3389/fmed.2023.1224922 Text en Copyright © 2023 Merad, Conrad, Brosset, Schmidt, Hanriat, Lustig, Laurent, Kolenda, Roussel-Gaillard, Batailler, Ferry and Lyon BJI Study group. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Merad, Yanis Conrad, Anne Brosset, Sophie Schmidt, Axel Hanriat, Camille Lustig, Sebastien Laurent, Frederic Kolenda, Camille Roussel-Gaillard, Tiphaine Batailler, Cecile Ferry, Tristan Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales |
title | Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales |
title_full | Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales |
title_fullStr | Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales |
title_full_unstemmed | Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales |
title_short | Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales |
title_sort | case report: continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing enterobacterales |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435880/ https://www.ncbi.nlm.nih.gov/pubmed/37601796 http://dx.doi.org/10.3389/fmed.2023.1224922 |
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