Cargando…

Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review

Parathyroid adenomas are benign proliferative disorders of parathyroid glands. Patients typically exhibit hyperparathyroidism and elevated serum calcium levels due to elevated levels of parathyroid hormone (PTH). We report a newly diagnosed case of a rare pathological osteolytic lesion. Radiological...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jia, Tang, Gusheng, Peng, Ye, Cheng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435972/
https://www.ncbi.nlm.nih.gov/pubmed/37601648
http://dx.doi.org/10.3389/fonc.2023.1218863
_version_ 1785092224879427584
author Chen, Jia
Tang, Gusheng
Peng, Ye
Cheng, Hui
author_facet Chen, Jia
Tang, Gusheng
Peng, Ye
Cheng, Hui
author_sort Chen, Jia
collection PubMed
description Parathyroid adenomas are benign proliferative disorders of parathyroid glands. Patients typically exhibit hyperparathyroidism and elevated serum calcium levels due to elevated levels of parathyroid hormone (PTH). We report a newly diagnosed case of a rare pathological osteolytic lesion. Radiological evaluation revealed multiple bony lesions in multiple parts of the pelvis, vertebral body, and spinous process, suggesting hematological neoplasms or bone marrow metastatic carcinoma. The morphology revealed many abnormal cells in the bone marrow smear. Furthermore, serum calcium and PTH levels were significantly increased compared to normal levels. Doppler color ultrasound showed a thyroid mass (left), suspected parathyroid adenoma, thyroid, and isthmus nodular goiter (right). The patient underwent bilateral neck exploration with parathyroidectomy, and serum calcium and PTH levels significantly decreased on the second day after surgery and had a surgical cure.
format Online
Article
Text
id pubmed-10435972
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104359722023-08-19 Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review Chen, Jia Tang, Gusheng Peng, Ye Cheng, Hui Front Oncol Oncology Parathyroid adenomas are benign proliferative disorders of parathyroid glands. Patients typically exhibit hyperparathyroidism and elevated serum calcium levels due to elevated levels of parathyroid hormone (PTH). We report a newly diagnosed case of a rare pathological osteolytic lesion. Radiological evaluation revealed multiple bony lesions in multiple parts of the pelvis, vertebral body, and spinous process, suggesting hematological neoplasms or bone marrow metastatic carcinoma. The morphology revealed many abnormal cells in the bone marrow smear. Furthermore, serum calcium and PTH levels were significantly increased compared to normal levels. Doppler color ultrasound showed a thyroid mass (left), suspected parathyroid adenoma, thyroid, and isthmus nodular goiter (right). The patient underwent bilateral neck exploration with parathyroidectomy, and serum calcium and PTH levels significantly decreased on the second day after surgery and had a surgical cure. Frontiers Media S.A. 2023-08-03 /pmc/articles/PMC10435972/ /pubmed/37601648 http://dx.doi.org/10.3389/fonc.2023.1218863 Text en Copyright © 2023 Chen, Tang, Peng and Cheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Jia
Tang, Gusheng
Peng, Ye
Cheng, Hui
Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review
title Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review
title_full Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review
title_fullStr Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review
title_full_unstemmed Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review
title_short Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review
title_sort parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435972/
https://www.ncbi.nlm.nih.gov/pubmed/37601648
http://dx.doi.org/10.3389/fonc.2023.1218863
work_keys_str_mv AT chenjia parathyroidadenomawithrareseverepathologicalosteolyticlesionacasereportandliteraturereview
AT tanggusheng parathyroidadenomawithrareseverepathologicalosteolyticlesionacasereportandliteraturereview
AT pengye parathyroidadenomawithrareseverepathologicalosteolyticlesionacasereportandliteraturereview
AT chenghui parathyroidadenomawithrareseverepathologicalosteolyticlesionacasereportandliteraturereview