Cargando…
Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review
Parathyroid adenomas are benign proliferative disorders of parathyroid glands. Patients typically exhibit hyperparathyroidism and elevated serum calcium levels due to elevated levels of parathyroid hormone (PTH). We report a newly diagnosed case of a rare pathological osteolytic lesion. Radiological...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435972/ https://www.ncbi.nlm.nih.gov/pubmed/37601648 http://dx.doi.org/10.3389/fonc.2023.1218863 |
_version_ | 1785092224879427584 |
---|---|
author | Chen, Jia Tang, Gusheng Peng, Ye Cheng, Hui |
author_facet | Chen, Jia Tang, Gusheng Peng, Ye Cheng, Hui |
author_sort | Chen, Jia |
collection | PubMed |
description | Parathyroid adenomas are benign proliferative disorders of parathyroid glands. Patients typically exhibit hyperparathyroidism and elevated serum calcium levels due to elevated levels of parathyroid hormone (PTH). We report a newly diagnosed case of a rare pathological osteolytic lesion. Radiological evaluation revealed multiple bony lesions in multiple parts of the pelvis, vertebral body, and spinous process, suggesting hematological neoplasms or bone marrow metastatic carcinoma. The morphology revealed many abnormal cells in the bone marrow smear. Furthermore, serum calcium and PTH levels were significantly increased compared to normal levels. Doppler color ultrasound showed a thyroid mass (left), suspected parathyroid adenoma, thyroid, and isthmus nodular goiter (right). The patient underwent bilateral neck exploration with parathyroidectomy, and serum calcium and PTH levels significantly decreased on the second day after surgery and had a surgical cure. |
format | Online Article Text |
id | pubmed-10435972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104359722023-08-19 Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review Chen, Jia Tang, Gusheng Peng, Ye Cheng, Hui Front Oncol Oncology Parathyroid adenomas are benign proliferative disorders of parathyroid glands. Patients typically exhibit hyperparathyroidism and elevated serum calcium levels due to elevated levels of parathyroid hormone (PTH). We report a newly diagnosed case of a rare pathological osteolytic lesion. Radiological evaluation revealed multiple bony lesions in multiple parts of the pelvis, vertebral body, and spinous process, suggesting hematological neoplasms or bone marrow metastatic carcinoma. The morphology revealed many abnormal cells in the bone marrow smear. Furthermore, serum calcium and PTH levels were significantly increased compared to normal levels. Doppler color ultrasound showed a thyroid mass (left), suspected parathyroid adenoma, thyroid, and isthmus nodular goiter (right). The patient underwent bilateral neck exploration with parathyroidectomy, and serum calcium and PTH levels significantly decreased on the second day after surgery and had a surgical cure. Frontiers Media S.A. 2023-08-03 /pmc/articles/PMC10435972/ /pubmed/37601648 http://dx.doi.org/10.3389/fonc.2023.1218863 Text en Copyright © 2023 Chen, Tang, Peng and Cheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Chen, Jia Tang, Gusheng Peng, Ye Cheng, Hui Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review |
title | Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review |
title_full | Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review |
title_fullStr | Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review |
title_full_unstemmed | Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review |
title_short | Parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review |
title_sort | parathyroid adenoma with rare severe pathological osteolytic lesion: a case report and literature review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435972/ https://www.ncbi.nlm.nih.gov/pubmed/37601648 http://dx.doi.org/10.3389/fonc.2023.1218863 |
work_keys_str_mv | AT chenjia parathyroidadenomawithrareseverepathologicalosteolyticlesionacasereportandliteraturereview AT tanggusheng parathyroidadenomawithrareseverepathologicalosteolyticlesionacasereportandliteraturereview AT pengye parathyroidadenomawithrareseverepathologicalosteolyticlesionacasereportandliteraturereview AT chenghui parathyroidadenomawithrareseverepathologicalosteolyticlesionacasereportandliteraturereview |