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A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance
Cancer cells make extensive use of the folate cycle to sustain increased anabolic metabolism. Multiple chemotherapeutic drugs interfere with the folate cycle, including methotrexate and 5-fluorouracil that are commonly applied for the treatment of leukemia and colorectal cancer (CRC), respectively....
Autores principales: | van der Krift, Felix, Zijlmans, Dick W, Shukla, Rhythm, Javed, Ali, Koukos, Panagiotis I, Schwarz, Laura LE, Timmermans-Sprang, Elpetra PM, Maas, Peter EM, Gahtory, Digvijay, van den Nieuwboer, Maurits, Mol, Jan A, Strous, Ger J, Bonvin, Alexandre MJJ, van der Stelt, Mario, Veldhuizen, Edwin JA, Weingarth, Markus, Vermeulen, Michiel, Klumperman, Judith, Maurice, Madelon M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435995/ https://www.ncbi.nlm.nih.gov/pubmed/37591722 http://dx.doi.org/10.26508/lsa.202302058 |
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