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Perfluorocarbons: A perspective of theranostic applications and challenges

Perfluorocarbon (PFC) are biocompatible compounds, chemically and biologically inert, and lacks toxicity as oxygen carriers. PFCs nanoemulsions and nanoparticles (NPs) are highly used in diagnostic imaging and enable novel imaging technology in clinical imaging modalities to notice and image patholo...

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Autores principales: Kakaei, Nasrin, Amirian, Roshanak, Azadi, Mehdi, Mohammadi, Ghobad, Izadi, Zhila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436007/
https://www.ncbi.nlm.nih.gov/pubmed/37600314
http://dx.doi.org/10.3389/fbioe.2023.1115254
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author Kakaei, Nasrin
Amirian, Roshanak
Azadi, Mehdi
Mohammadi, Ghobad
Izadi, Zhila
author_facet Kakaei, Nasrin
Amirian, Roshanak
Azadi, Mehdi
Mohammadi, Ghobad
Izadi, Zhila
author_sort Kakaei, Nasrin
collection PubMed
description Perfluorocarbon (PFC) are biocompatible compounds, chemically and biologically inert, and lacks toxicity as oxygen carriers. PFCs nanoemulsions and nanoparticles (NPs) are highly used in diagnostic imaging and enable novel imaging technology in clinical imaging modalities to notice and image pathological and physiological alterations. Therapeutics with PFCs such as the innovative approach to preventing thrombus formation, PFC nanodroplets utilized in ultrasonic medication delivery in arthritis, or PFC-based NPs such as Perfluortributylamine (PFTBA), Pentafluorophenyl (PFP), Perfluorohexan (PFH), Perfluorooctyl bromide (PFOB), and others, recently become renowned for oxygenating tumors and enhancing the effects of anticancer treatments as oxygen carriers for tumor hypoxia. In this review, we will discuss the recent advancements that have been made in PFC’s applications in theranostic (therapeutics and diagnostics) as well as assess the benefits and drawbacks of these applications.
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spelling pubmed-104360072023-08-19 Perfluorocarbons: A perspective of theranostic applications and challenges Kakaei, Nasrin Amirian, Roshanak Azadi, Mehdi Mohammadi, Ghobad Izadi, Zhila Front Bioeng Biotechnol Bioengineering and Biotechnology Perfluorocarbon (PFC) are biocompatible compounds, chemically and biologically inert, and lacks toxicity as oxygen carriers. PFCs nanoemulsions and nanoparticles (NPs) are highly used in diagnostic imaging and enable novel imaging technology in clinical imaging modalities to notice and image pathological and physiological alterations. Therapeutics with PFCs such as the innovative approach to preventing thrombus formation, PFC nanodroplets utilized in ultrasonic medication delivery in arthritis, or PFC-based NPs such as Perfluortributylamine (PFTBA), Pentafluorophenyl (PFP), Perfluorohexan (PFH), Perfluorooctyl bromide (PFOB), and others, recently become renowned for oxygenating tumors and enhancing the effects of anticancer treatments as oxygen carriers for tumor hypoxia. In this review, we will discuss the recent advancements that have been made in PFC’s applications in theranostic (therapeutics and diagnostics) as well as assess the benefits and drawbacks of these applications. Frontiers Media S.A. 2023-08-03 /pmc/articles/PMC10436007/ /pubmed/37600314 http://dx.doi.org/10.3389/fbioe.2023.1115254 Text en Copyright © 2023 Kakaei, Amirian, Azadi, Mohammadi and Izadi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Kakaei, Nasrin
Amirian, Roshanak
Azadi, Mehdi
Mohammadi, Ghobad
Izadi, Zhila
Perfluorocarbons: A perspective of theranostic applications and challenges
title Perfluorocarbons: A perspective of theranostic applications and challenges
title_full Perfluorocarbons: A perspective of theranostic applications and challenges
title_fullStr Perfluorocarbons: A perspective of theranostic applications and challenges
title_full_unstemmed Perfluorocarbons: A perspective of theranostic applications and challenges
title_short Perfluorocarbons: A perspective of theranostic applications and challenges
title_sort perfluorocarbons: a perspective of theranostic applications and challenges
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436007/
https://www.ncbi.nlm.nih.gov/pubmed/37600314
http://dx.doi.org/10.3389/fbioe.2023.1115254
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