In vitro and in vivo efficacy of Molnupiravir against Zika virus infections

• Molnupiravir exhibits effective antiviral activity against ZIKV in vitro. • Intraperitoneal administration of Molnupiravir protects mice from lethal ZIKV challenge. • Molnupiravir might act on the replication phase of the ZIKV life cycle.

Detalles Bibliográficos
Autores principales: Wang, Zhuang, Yang, Shaokang, Dai, Qingsong, Guo, Xiaojia, Li, Yuexiang, Li, Wei, Yang, Xiaotong, Yang, Jingjing, Yan, Xintong, Tao, Huimin, Luo, Chongda, Li, Song, Chen, Xingjuan, Cao, Ruiyuan, Zhong, Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2023
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436044/
https://www.ncbi.nlm.nih.gov/pubmed/37268161
http://dx.doi.org/10.1016/j.virs.2023.05.011
Descripción
Sumario:• Molnupiravir exhibits effective antiviral activity against ZIKV in vitro. • Intraperitoneal administration of Molnupiravir protects mice from lethal ZIKV challenge. • Molnupiravir might act on the replication phase of the ZIKV life cycle.

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