Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding

The Dicistroviridae is a virus family that includes many insect pathogens. These viruses contain a positive-sense RNA genome that is replicated by the virally encoded RNA-dependent RNA polymerase (RdRP) also named 3D(pol). Compared with the Picornaviridae RdRPs such as poliovirus (PV) 3D(pol), the D...

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Detalles Bibliográficos
Autores principales: Fang, Xiang, Lu, Guoliang, Deng, Yanchun, Yang, Sa, Hou, Chunsheng, Gong, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436059/
https://www.ncbi.nlm.nih.gov/pubmed/37156298
http://dx.doi.org/10.1016/j.virs.2023.05.002

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