The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population

INTRODUCTION: The imbalance between Th17 and regulatory T cells in inflammatory bowel diseases (IBD) promotes intestinal epithelial cell damage. In this scenario, T helper cell lineage commitment is accompanied by dynamic changes to the chromatin that facilitate or repress gene expression. METHODS:...

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Detalles Bibliográficos
Autores principales: Medina, Tiago S., Murison, Alex, Smith, Michelle, Kinker, Gabriela S., Chakravarthy, Ankur, Vitiello, Glauco A. F., Turpin, Williams, Shen, Shu Yi, Yau, Helen L., Sarmento, Olga F., Faubion, William, Lupien, Mathieu, Silverberg, Mark S., Arrowsmith, Cheryl H., De Carvalho, Daniel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436103/
https://www.ncbi.nlm.nih.gov/pubmed/37600767
http://dx.doi.org/10.3389/fimmu.2023.1161901

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