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SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection

A key question in the coronavirus disease 2019 (COVID-19) pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) post primary infection, which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure t...

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Autores principales: Li, Ziwei, Xiang, Tiandan, Liang, Boyun, Liu, Jing, Deng, Hui, Yang, Xuecheng, Wang, Hua, Feng, Xuemei, Zelinskyy, Gennadiy, Trilling, Mirko, Sutter, Kathrin, Lu, Mengji, Dittmer, Ulf, Wang, Baoju, Yang, Dongliang, Zheng, Xin, Liu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436107/
https://www.ncbi.nlm.nih.gov/pubmed/37414153
http://dx.doi.org/10.1016/j.virs.2023.06.011
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author Li, Ziwei
Xiang, Tiandan
Liang, Boyun
Liu, Jing
Deng, Hui
Yang, Xuecheng
Wang, Hua
Feng, Xuemei
Zelinskyy, Gennadiy
Trilling, Mirko
Sutter, Kathrin
Lu, Mengji
Dittmer, Ulf
Wang, Baoju
Yang, Dongliang
Zheng, Xin
Liu, Jia
author_facet Li, Ziwei
Xiang, Tiandan
Liang, Boyun
Liu, Jing
Deng, Hui
Yang, Xuecheng
Wang, Hua
Feng, Xuemei
Zelinskyy, Gennadiy
Trilling, Mirko
Sutter, Kathrin
Lu, Mengji
Dittmer, Ulf
Wang, Baoju
Yang, Dongliang
Zheng, Xin
Liu, Jia
author_sort Li, Ziwei
collection PubMed
description A key question in the coronavirus disease 2019 (COVID-19) pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) post primary infection, which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the virus. Here, we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals (CIs) that were among the first to be infected worldwide and without any possible antigen re-exposure since then. The magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs. The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82% and 76%, respectively, over the time period of ten months after infection. Accordingly, the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75% of CIs during the follow-up. Collectively, we provide a comprehensive characterization of the long-term memory T cell response in CIs, suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected.
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spelling pubmed-104361072023-08-19 SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection Li, Ziwei Xiang, Tiandan Liang, Boyun Liu, Jing Deng, Hui Yang, Xuecheng Wang, Hua Feng, Xuemei Zelinskyy, Gennadiy Trilling, Mirko Sutter, Kathrin Lu, Mengji Dittmer, Ulf Wang, Baoju Yang, Dongliang Zheng, Xin Liu, Jia Virol Sin Research Article A key question in the coronavirus disease 2019 (COVID-19) pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) post primary infection, which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the virus. Here, we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals (CIs) that were among the first to be infected worldwide and without any possible antigen re-exposure since then. The magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs. The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82% and 76%, respectively, over the time period of ten months after infection. Accordingly, the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75% of CIs during the follow-up. Collectively, we provide a comprehensive characterization of the long-term memory T cell response in CIs, suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected. Wuhan Institute of Virology, Chinese Academy of Sciences 2023-07-04 /pmc/articles/PMC10436107/ /pubmed/37414153 http://dx.doi.org/10.1016/j.virs.2023.06.011 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Li, Ziwei
Xiang, Tiandan
Liang, Boyun
Liu, Jing
Deng, Hui
Yang, Xuecheng
Wang, Hua
Feng, Xuemei
Zelinskyy, Gennadiy
Trilling, Mirko
Sutter, Kathrin
Lu, Mengji
Dittmer, Ulf
Wang, Baoju
Yang, Dongliang
Zheng, Xin
Liu, Jia
SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
title SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
title_full SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
title_fullStr SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
title_full_unstemmed SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
title_short SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
title_sort sars-cov-2-specific t cell responses wane profoundly in convalescent individuals 10 months after primary infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436107/
https://www.ncbi.nlm.nih.gov/pubmed/37414153
http://dx.doi.org/10.1016/j.virs.2023.06.011
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