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The significance of ERK5 catalytic-independent functions in disease pathways
Extracellular signal-regulated kinase 5 (ERK5), also known as BMK1 or MAPK7, represents a recent addition to the classical mitogen-activated protein kinase (MAPK) family. This family includes well-known members such as ERK1/2, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436230/ https://www.ncbi.nlm.nih.gov/pubmed/37601096 http://dx.doi.org/10.3389/fcell.2023.1235217 |
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author | Le, Nhat-Tu |
author_facet | Le, Nhat-Tu |
author_sort | Le, Nhat-Tu |
collection | PubMed |
description | Extracellular signal-regulated kinase 5 (ERK5), also known as BMK1 or MAPK7, represents a recent addition to the classical mitogen-activated protein kinase (MAPK) family. This family includes well-known members such as ERK1/2, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), as well as atypical MAPKs such as ERK3, ERK4, ERK7 (ERK8), and Nemo-like kinase (NLK). Comprehensive reviews available elsewhere provide detailed insights into ERK5, which interested readers can refer to for in-depth knowledge (Nithianandarajah-Jones et al., 2012; Monti et al., Cancers (Basel), 2022, 14). The primary aim of this review is to emphasize the essential characteristics of ERK5 and shed light on the intricate nature of its activation, with particular attention to the catalytic-independent functions in disease pathways. |
format | Online Article Text |
id | pubmed-10436230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104362302023-08-19 The significance of ERK5 catalytic-independent functions in disease pathways Le, Nhat-Tu Front Cell Dev Biol Cell and Developmental Biology Extracellular signal-regulated kinase 5 (ERK5), also known as BMK1 or MAPK7, represents a recent addition to the classical mitogen-activated protein kinase (MAPK) family. This family includes well-known members such as ERK1/2, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), as well as atypical MAPKs such as ERK3, ERK4, ERK7 (ERK8), and Nemo-like kinase (NLK). Comprehensive reviews available elsewhere provide detailed insights into ERK5, which interested readers can refer to for in-depth knowledge (Nithianandarajah-Jones et al., 2012; Monti et al., Cancers (Basel), 2022, 14). The primary aim of this review is to emphasize the essential characteristics of ERK5 and shed light on the intricate nature of its activation, with particular attention to the catalytic-independent functions in disease pathways. Frontiers Media S.A. 2023-08-04 /pmc/articles/PMC10436230/ /pubmed/37601096 http://dx.doi.org/10.3389/fcell.2023.1235217 Text en Copyright © 2023 Le. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Le, Nhat-Tu The significance of ERK5 catalytic-independent functions in disease pathways |
title | The significance of ERK5 catalytic-independent functions in disease pathways |
title_full | The significance of ERK5 catalytic-independent functions in disease pathways |
title_fullStr | The significance of ERK5 catalytic-independent functions in disease pathways |
title_full_unstemmed | The significance of ERK5 catalytic-independent functions in disease pathways |
title_short | The significance of ERK5 catalytic-independent functions in disease pathways |
title_sort | significance of erk5 catalytic-independent functions in disease pathways |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436230/ https://www.ncbi.nlm.nih.gov/pubmed/37601096 http://dx.doi.org/10.3389/fcell.2023.1235217 |
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