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Chemoenzymatic Synthesis of 3′-Deoxy-3′,4′-didehydro-cytidine triphosphate (ddhCTP)

[Image: see text] 3′-Deoxy-3′,4′-didehydro-cytidine triphosphate (ddhCTP) is a novel antiviral molecule produced by the enzyme viperin during the early stages of the innate immune response. ddhCTP has been shown to act as a chain terminator of flavivirus RNA-dependent RNA polymerases. To date, synth...

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Detalles Bibliográficos
Autores principales:	Lee, James H., Wood, James M., Almo, Steven C., Evans, Gary B., Harris, Lawrence D., Grove, Tyler L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436258/ https://www.ncbi.nlm.nih.gov/pubmed/37599790 http://dx.doi.org/10.1021/acsbiomedchemau.3c00014

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