Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity

[Image: see text] Amino acid ester prodrugs of the thiazolides, introduced to improve the pharmacokinetic parameters of the parent drugs, proved to be stable as their salts but were unstable at pH > 5. Although some of the instability was due to simple hydrolysis, we have found that the main end...

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Detalles Bibliográficos
Autores principales: Stachulski, Andrew V., Rossignol, Jean-Francois, Pate, Sophie, Taujanskas, Joshua, Iggo, Jonathan A., Aerts, Rudi, Pascal, Etienne, Piacentini, Sara, La Frazia, Simone, Santoro, M. Gabriella, van Vooren, Lieven, Sintubin, Liesje, Cooper, Mark, Swift, Karl, O’Neill, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436260/
https://www.ncbi.nlm.nih.gov/pubmed/37599793
http://dx.doi.org/10.1021/acsbiomedchemau.2c00083

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