Cargando…

Structure-Based Design of Inhibitors of the m(6)A-RNA Writer Enzyme METTL3

[Image: see text] Methyltransferase-like 3 (METTL3) and METTL14 form a heterodimeric complex that catalyzes the most abundant internal mRNA modification, N(6)-methyladenosine (m(6)A). METTL3 is the catalytic subunit that binds the co-substrate S-adenosyl methionine (SAM), while METTL14 is involved i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bedi, Rajiv Kumar, Huang, Danzhi, Li, Yaozong, Caflisch, Amedeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436262/ https://www.ncbi.nlm.nih.gov/pubmed/37599794 http://dx.doi.org/10.1021/acsbiomedchemau.3c00023

Ejemplares similares

METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes
por: Moroz‐Omori, Elena V., et al.
Publicado: (2021)

Methylation of Structured RNA by the m(6)A Writer METTL16 Is Essential for Mouse Embryonic Development
por: Mendel, Mateusz, et al.
Publicado: (2018)

Fragment Ligands of the m(6)A-RNA Reader YTHDF2
por: Nai, Francesco, et al.
Publicado: (2022)

The Comprehensive Analysis of N6-Methyadenosine Writer METTL3 and METTL14 in Gastric Cancer
por: Ge, Yiling, et al.
Publicado: (2023)

The Free Energy Landscape of Small Molecule Unbinding
por: Huang, Danzhi, et al.
Publicado: (2011)

Reinvestigating the clinical relevance of the m(6)A writer METTL3 in urothelial carcinoma of the bladder
por: Koch, Jonas, et al.
Publicado: (2023)

WTAP–VIRMA counteracts dsDNA binding of the m(6)A writer METTL3–METTL14 complex and maintains N(6)-adenosine methylation activity
por: Yan, Xuhui, et al.
Publicado: (2023)

N(6)-methyladenosine (m(6)A) writer METTL3 accelerates the apoptosis of vascular endothelial cells in high glucose
por: Li, Zhenjin, et al.
Publicado: (2023)

Downregulation of m(6)A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness
por: Guimarães‐Teixeira, Catarina, et al.
Publicado: (2022)

M6A “Writer” Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer
por: Cai, Changjing, et al.
Publicado: (2021)

The novel m6A writer METTL5 as prognostic biomarker probably associating with the regulation of immune microenvironment in kidney cancer
por: Wei Zhang, et al.
Publicado: (2022)

The RNA m(6)A writer WTAP in diseases: structure, roles, and mechanisms
por: Huang, Qibo, et al.
Publicado: (2022)

Marking RNA: m(6)A writers, readers, and functions in Arabidopsis
por: Reichel, Marlene, et al.
Publicado: (2019)

Structural insights into the molecular mechanism of the m(6)A writer complex
por: Śledź, Paweł, et al.
Publicado: (2016)

Cryo-EM structures of human m(6)A writer complexes
por: Su, Shichen, et al.
Publicado: (2022)

Novel circGFRα1 Promotes Self-Renewal of Female Germline Stem Cells Mediated by m(6)A Writer METTL14
por: Li, Xiaoyong, et al.
Publicado: (2021)

Alternative splicing of METTL3 explains apparently METTL3-independent m(6)A modifications in mRNA
por: Poh, Hui Xian, et al.
Publicado: (2022)

The detection and functions of RNA modification m(6)A based on m(6)A writers and erasers
por: Zhang, Wei, et al.
Publicado: (2021)

Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase
por: Huang, Jinbo, et al.
Publicado: (2018)

The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes
por: Arcidiacono, Orazio Angelo, et al.
Publicado: (2020)

Crystal structure of human METTL6, the m(3)C methyltransferase
por: Chen, Ran, et al.
Publicado: (2021)

Role of m6A writers, erasers and readers in cancer
por: Fang, Zhen, et al.
Publicado: (2022)

Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6
por: Mao, Xue-Ling, et al.
Publicado: (2021)

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

Novel insights into the m(6)A-RNA methyltransferase METTL3 in cancer
por: Cai, Yiqing, et al.
Publicado: (2021)

Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism
por: Yang, Ying, et al.
Publicado: (2018)

Interactions, localization, and phosphorylation of the m(6)A generating METTL3–METTL14–WTAP complex
por: Schöller, Eva, et al.
Publicado: (2018)

A cryptic pocket in METTL3-METTL14 regulates m(6)A conversion and sensing
por: Qi, Shan, et al.
Publicado: (2023)

SUMOylation of the m(6)A-RNA methyltransferase METTL3 modulates its function
por: Du, Yuzhang, et al.
Publicado: (2018)

Effects of writers, erasers and readers within miRNA‐related m6A modification in cancers
por: Feng, Huiru, et al.
Publicado: (2022)

Mettl3-mediated mRNA m(6)A methylation promotes dendritic cell activation
por: Wang, Huamin, et al.
Publicado: (2019)

The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal and leukemia cells
por: Vu, Ly P., et al.
Publicado: (2017)

DARS-AS1 recruits METTL3/METTL14 to bind and enhance DARS mRNA m(6)A modification and translation for cytoprotective autophagy in cervical cancer
por: Zhu, Miaohua, et al.
Publicado: (2022)

Mechanistic insights into m(6)A modification of U6 snRNA by human METTL16
por: Aoyama, Tomohiko, et al.
Publicado: (2020)

Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking
por: Ekonomiuk, Dariusz, et al.
Publicado: (2009)

Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver
por: Chen, Liming, et al.
Publicado: (2019)

The N(6)-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
por: Dorn, Lisa E., et al.
Publicado: (2019)

The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs
por: Ignatova, Valentina V., et al.
Publicado: (2020)

METTL3-Mediated m(6)A RNA Modification Regulates Corneal Injury Repair
por: Dai, Yarong, et al.
Publicado: (2021)

The Role of the m(6)A RNA Methyltransferase METTL16 in Gene Expression and SAM Homeostasis
por: Mermoud, Jacqueline E.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tsonrmisfhis1s5um4urg0ghnh