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Structure-Based Design of Inhibitors of the m(6)A-RNA Writer Enzyme METTL3

[Image: see text] Methyltransferase-like 3 (METTL3) and METTL14 form a heterodimeric complex that catalyzes the most abundant internal mRNA modification, N(6)-methyladenosine (m(6)A). METTL3 is the catalytic subunit that binds the co-substrate S-adenosyl methionine (SAM), while METTL14 is involved i...

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Detalles Bibliográficos
Autores principales:	Bedi, Rajiv Kumar, Huang, Danzhi, Li, Yaozong, Caflisch, Amedeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436262/ https://www.ncbi.nlm.nih.gov/pubmed/37599794 http://dx.doi.org/10.1021/acsbiomedchemau.3c00023

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