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Mechanisms of alkaliptosis

Malignant tumors represent a major threat to global health and the search for effective treatments is imperative. While various treatments exist, including surgery, radiotherapy, chemotherapy, immunotherapy and combination therapies, there remains a need to develop therapies that target regulated ce...

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Detalles Bibliográficos
Autores principales: Chen, Fangquan, Kang, Rui, Liu, Jiao, Tang, Daolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436304/
https://www.ncbi.nlm.nih.gov/pubmed/37601110
http://dx.doi.org/10.3389/fcell.2023.1213995
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author Chen, Fangquan
Kang, Rui
Liu, Jiao
Tang, Daolin
author_facet Chen, Fangquan
Kang, Rui
Liu, Jiao
Tang, Daolin
author_sort Chen, Fangquan
collection PubMed
description Malignant tumors represent a major threat to global health and the search for effective treatments is imperative. While various treatments exist, including surgery, radiotherapy, chemotherapy, immunotherapy and combination therapies, there remains a need to develop therapies that target regulated cell death pathways to eliminate cancer cells while preserving normal cells. Alkaliptosis, a pH-dependent cell death process triggered by the small molecular compound JTC801, has been identified as a novel approach for malignant tumor treatment, particularly in pancreatic cancer. Two major signaling pathways, the NF-κB-CA9 pathway and the ATP6V0D1-STAT3 pathway, contribute to the induction of alkaliptosis. This review summarizes recent developments in our understanding of alkaliptosis signals, mechanisms, and modulation, and explores its context-dependent effects on drug resistance, inflammation, and immunity. By providing a deeper understanding of the heterogeneity and plasticity of cell death mechanisms, this information holds promise for informing the design of more effective anti-tumor therapies.
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spelling pubmed-104363042023-08-19 Mechanisms of alkaliptosis Chen, Fangquan Kang, Rui Liu, Jiao Tang, Daolin Front Cell Dev Biol Cell and Developmental Biology Malignant tumors represent a major threat to global health and the search for effective treatments is imperative. While various treatments exist, including surgery, radiotherapy, chemotherapy, immunotherapy and combination therapies, there remains a need to develop therapies that target regulated cell death pathways to eliminate cancer cells while preserving normal cells. Alkaliptosis, a pH-dependent cell death process triggered by the small molecular compound JTC801, has been identified as a novel approach for malignant tumor treatment, particularly in pancreatic cancer. Two major signaling pathways, the NF-κB-CA9 pathway and the ATP6V0D1-STAT3 pathway, contribute to the induction of alkaliptosis. This review summarizes recent developments in our understanding of alkaliptosis signals, mechanisms, and modulation, and explores its context-dependent effects on drug resistance, inflammation, and immunity. By providing a deeper understanding of the heterogeneity and plasticity of cell death mechanisms, this information holds promise for informing the design of more effective anti-tumor therapies. Frontiers Media S.A. 2023-08-04 /pmc/articles/PMC10436304/ /pubmed/37601110 http://dx.doi.org/10.3389/fcell.2023.1213995 Text en Copyright © 2023 Chen, Kang, Liu and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Fangquan
Kang, Rui
Liu, Jiao
Tang, Daolin
Mechanisms of alkaliptosis
title Mechanisms of alkaliptosis
title_full Mechanisms of alkaliptosis
title_fullStr Mechanisms of alkaliptosis
title_full_unstemmed Mechanisms of alkaliptosis
title_short Mechanisms of alkaliptosis
title_sort mechanisms of alkaliptosis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436304/
https://www.ncbi.nlm.nih.gov/pubmed/37601110
http://dx.doi.org/10.3389/fcell.2023.1213995
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