Advances in the study of acetaminophen-induced liver injury

Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and acute liver failure. The diagnosis, screening, and management of APAP-induced liver injury (AILI) is challenging because of the complex mechanisms involved. Starting from the current studies on the mechanisms of AI...

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Detalles Bibliográficos
Autores principales: Li, Xinghui, Ni, Jiaqi, Chen, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436315/
https://www.ncbi.nlm.nih.gov/pubmed/37601069
http://dx.doi.org/10.3389/fphar.2023.1239395
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author Li, Xinghui
Ni, Jiaqi
Chen, Li
author_facet Li, Xinghui
Ni, Jiaqi
Chen, Li
author_sort Li, Xinghui
collection PubMed
description Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and acute liver failure. The diagnosis, screening, and management of APAP-induced liver injury (AILI) is challenging because of the complex mechanisms involved. Starting from the current studies on the mechanisms of AILI, this review focuses on novel findings in the field of diagnosis, screening, and management of AILI. It highlights the current issues that need to be addressed. This review is supposed to summarize the recent research progress and make recommendations for future research.
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spelling pubmed-104363152023-08-19 Advances in the study of acetaminophen-induced liver injury Li, Xinghui Ni, Jiaqi Chen, Li Front Pharmacol Pharmacology Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and acute liver failure. The diagnosis, screening, and management of APAP-induced liver injury (AILI) is challenging because of the complex mechanisms involved. Starting from the current studies on the mechanisms of AILI, this review focuses on novel findings in the field of diagnosis, screening, and management of AILI. It highlights the current issues that need to be addressed. This review is supposed to summarize the recent research progress and make recommendations for future research. Frontiers Media S.A. 2023-08-04 /pmc/articles/PMC10436315/ /pubmed/37601069 http://dx.doi.org/10.3389/fphar.2023.1239395 Text en Copyright © 2023 Li, Ni and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Xinghui
Ni, Jiaqi
Chen, Li
Advances in the study of acetaminophen-induced liver injury
title Advances in the study of acetaminophen-induced liver injury
title_full Advances in the study of acetaminophen-induced liver injury
title_fullStr Advances in the study of acetaminophen-induced liver injury
title_full_unstemmed Advances in the study of acetaminophen-induced liver injury
title_short Advances in the study of acetaminophen-induced liver injury
title_sort advances in the study of acetaminophen-induced liver injury
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436315/
https://www.ncbi.nlm.nih.gov/pubmed/37601069
http://dx.doi.org/10.3389/fphar.2023.1239395
work_keys_str_mv AT lixinghui advancesinthestudyofacetaminopheninducedliverinjury
AT nijiaqi advancesinthestudyofacetaminopheninducedliverinjury
AT chenli advancesinthestudyofacetaminopheninducedliverinjury

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