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Case report: Coxiella burnetii endocarditis in the absence of evident exposure
Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. In humans, it can manifest clinically as an acute or chronic disease and endocarditis, the most frequent complication of chronic Q fever is associated with the greatest morbidity and mortality. We report a severe case of endocardit...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436321/ https://www.ncbi.nlm.nih.gov/pubmed/37601776 http://dx.doi.org/10.3389/fmed.2023.1220205 |
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author | Bozza, Silvia Graziani, Alessandro Borghi, Monica Marini, Daniele Duranti, Michele Camilloni, Barbara |
author_facet | Bozza, Silvia Graziani, Alessandro Borghi, Monica Marini, Daniele Duranti, Michele Camilloni, Barbara |
author_sort | Bozza, Silvia |
collection | PubMed |
description | Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. In humans, it can manifest clinically as an acute or chronic disease and endocarditis, the most frequent complication of chronic Q fever is associated with the greatest morbidity and mortality. We report a severe case of endocarditis in a 55-year-old man with a history of aortic valve replacement affected by monoclonal gammopathy of undetermined significance (MGUS), and living in a non-endemic area for C. burnetii. After two episodes of fever of unknown origin (FUO), occurring 2 years apart and characterized by negative blood cultures, a serological diagnosis of Q fever endocarditis was performed even though the patient did not refer to possible past exposure to C. burnetii. Since people with preexisting valvular heart disease, when infected with C. burnetii, have reported a 40% risk of Q fever endocarditis, clinicians should maintain a high index of suspicion for infective endocarditis in all patients with FUO even when the exposure to C. burnetii appears to be unlikely. |
format | Online Article Text |
id | pubmed-10436321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104363212023-08-19 Case report: Coxiella burnetii endocarditis in the absence of evident exposure Bozza, Silvia Graziani, Alessandro Borghi, Monica Marini, Daniele Duranti, Michele Camilloni, Barbara Front Med (Lausanne) Medicine Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. In humans, it can manifest clinically as an acute or chronic disease and endocarditis, the most frequent complication of chronic Q fever is associated with the greatest morbidity and mortality. We report a severe case of endocarditis in a 55-year-old man with a history of aortic valve replacement affected by monoclonal gammopathy of undetermined significance (MGUS), and living in a non-endemic area for C. burnetii. After two episodes of fever of unknown origin (FUO), occurring 2 years apart and characterized by negative blood cultures, a serological diagnosis of Q fever endocarditis was performed even though the patient did not refer to possible past exposure to C. burnetii. Since people with preexisting valvular heart disease, when infected with C. burnetii, have reported a 40% risk of Q fever endocarditis, clinicians should maintain a high index of suspicion for infective endocarditis in all patients with FUO even when the exposure to C. burnetii appears to be unlikely. Frontiers Media S.A. 2023-08-04 /pmc/articles/PMC10436321/ /pubmed/37601776 http://dx.doi.org/10.3389/fmed.2023.1220205 Text en Copyright © 2023 Bozza, Graziani, Borghi, Marini, Duranti and Camilloni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Bozza, Silvia Graziani, Alessandro Borghi, Monica Marini, Daniele Duranti, Michele Camilloni, Barbara Case report: Coxiella burnetii endocarditis in the absence of evident exposure |
title | Case report: Coxiella burnetii endocarditis in the absence of evident exposure |
title_full | Case report: Coxiella burnetii endocarditis in the absence of evident exposure |
title_fullStr | Case report: Coxiella burnetii endocarditis in the absence of evident exposure |
title_full_unstemmed | Case report: Coxiella burnetii endocarditis in the absence of evident exposure |
title_short | Case report: Coxiella burnetii endocarditis in the absence of evident exposure |
title_sort | case report: coxiella burnetii endocarditis in the absence of evident exposure |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436321/ https://www.ncbi.nlm.nih.gov/pubmed/37601776 http://dx.doi.org/10.3389/fmed.2023.1220205 |
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