A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature

The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome can be potentially life-threatening. The diagnosis is sometimes difficult since the clinical manifestations may be incomplete or non-specific. Insulinoma is a rare functioning neuroendocrine tumor (NET) of the pancreas. Medical t...

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Autores principales: Lassoued, Najoua, Alaya, Wafa, Arfa, Sondos, Korbi, Mouna, Lassoued, Ines, Amor, Soumaya Ben, Zaouali, Fatma, Farhat, Zayneb, Chelly, Jihen, Habib Sfar, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436324/
https://www.ncbi.nlm.nih.gov/pubmed/37601782
http://dx.doi.org/10.3389/fmed.2023.1196041
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author Lassoued, Najoua
Alaya, Wafa
Arfa, Sondos
Korbi, Mouna
Lassoued, Ines
Amor, Soumaya Ben
Zaouali, Fatma
Farhat, Zayneb
Chelly, Jihen
Habib Sfar, Mohamed
author_facet Lassoued, Najoua
Alaya, Wafa
Arfa, Sondos
Korbi, Mouna
Lassoued, Ines
Amor, Soumaya Ben
Zaouali, Fatma
Farhat, Zayneb
Chelly, Jihen
Habib Sfar, Mohamed
author_sort Lassoued, Najoua
collection PubMed
description The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome can be potentially life-threatening. The diagnosis is sometimes difficult since the clinical manifestations may be incomplete or non-specific. Insulinoma is a rare functioning neuroendocrine tumor (NET) of the pancreas. Medical therapy may be needed when surgery is contraindicated, delayed or refused. Diazoxide is widely used to control hypoglycemia in patients with insulinoma. We report a clinical case of an insulinoma in a 85-year-old patient treated with diazoxide with a fatal outcome due to a delayed diagnosis of a DRESS syndrome. This is the first case of DRESS syndrome reported after using diazoxide for insulinoma treatment in our knowledge.
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spelling pubmed-104363242023-08-19 A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature Lassoued, Najoua Alaya, Wafa Arfa, Sondos Korbi, Mouna Lassoued, Ines Amor, Soumaya Ben Zaouali, Fatma Farhat, Zayneb Chelly, Jihen Habib Sfar, Mohamed Front Med (Lausanne) Medicine The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome can be potentially life-threatening. The diagnosis is sometimes difficult since the clinical manifestations may be incomplete or non-specific. Insulinoma is a rare functioning neuroendocrine tumor (NET) of the pancreas. Medical therapy may be needed when surgery is contraindicated, delayed or refused. Diazoxide is widely used to control hypoglycemia in patients with insulinoma. We report a clinical case of an insulinoma in a 85-year-old patient treated with diazoxide with a fatal outcome due to a delayed diagnosis of a DRESS syndrome. This is the first case of DRESS syndrome reported after using diazoxide for insulinoma treatment in our knowledge. Frontiers Media S.A. 2023-08-04 /pmc/articles/PMC10436324/ /pubmed/37601782 http://dx.doi.org/10.3389/fmed.2023.1196041 Text en Copyright © 2023 Lassoued, Alaya, Arfa, Korbi, Lassoued, Amor, Zaouali, Farhat, Chelly and Habib Sfar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Lassoued, Najoua
Alaya, Wafa
Arfa, Sondos
Korbi, Mouna
Lassoued, Ines
Amor, Soumaya Ben
Zaouali, Fatma
Farhat, Zayneb
Chelly, Jihen
Habib Sfar, Mohamed
A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature
title A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature
title_full A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature
title_fullStr A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature
title_full_unstemmed A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature
title_short A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature
title_sort posteriori diagnosis of dress syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436324/
https://www.ncbi.nlm.nih.gov/pubmed/37601782
http://dx.doi.org/10.3389/fmed.2023.1196041
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