New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength

Neostigmine is a clinical cholinesterase inhibitor, that is, commonly used to enhance the function of the cholinergic neuromuscular junction. Recent studies have shown that neostigmine regulates the immune-inflammatory response through the cholinergic anti-inflammatory pathway, affecting perioperati...

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Detalles Bibliográficos
Autores principales: Si, Shangkun, Zhao, Xiaohu, Su, Fan, Lu, Hongxiu, Zhang, Dongbin, Sun, Li, Wang, Fulei, Xu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436336/
https://www.ncbi.nlm.nih.gov/pubmed/37601044
http://dx.doi.org/10.3389/fphar.2023.1227496
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author Si, Shangkun
Zhao, Xiaohu
Su, Fan
Lu, Hongxiu
Zhang, Dongbin
Sun, Li
Wang, Fulei
Xu, Li
author_facet Si, Shangkun
Zhao, Xiaohu
Su, Fan
Lu, Hongxiu
Zhang, Dongbin
Sun, Li
Wang, Fulei
Xu, Li
author_sort Si, Shangkun
collection PubMed
description Neostigmine is a clinical cholinesterase inhibitor, that is, commonly used to enhance the function of the cholinergic neuromuscular junction. Recent studies have shown that neostigmine regulates the immune-inflammatory response through the cholinergic anti-inflammatory pathway, affecting perioperative neurocognitive function. This article reviews the relevant research evidence over the past 20 years, intending to provide new perspectives and strategies for the clinical application of neostigmine.
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spelling pubmed-104363362023-08-19 New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength Si, Shangkun Zhao, Xiaohu Su, Fan Lu, Hongxiu Zhang, Dongbin Sun, Li Wang, Fulei Xu, Li Front Pharmacol Pharmacology Neostigmine is a clinical cholinesterase inhibitor, that is, commonly used to enhance the function of the cholinergic neuromuscular junction. Recent studies have shown that neostigmine regulates the immune-inflammatory response through the cholinergic anti-inflammatory pathway, affecting perioperative neurocognitive function. This article reviews the relevant research evidence over the past 20 years, intending to provide new perspectives and strategies for the clinical application of neostigmine. Frontiers Media S.A. 2023-08-04 /pmc/articles/PMC10436336/ /pubmed/37601044 http://dx.doi.org/10.3389/fphar.2023.1227496 Text en Copyright © 2023 Si, Zhao, Su, Lu, Zhang, Sun, Wang and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Si, Shangkun
Zhao, Xiaohu
Su, Fan
Lu, Hongxiu
Zhang, Dongbin
Sun, Li
Wang, Fulei
Xu, Li
New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength
title New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength
title_full New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength
title_fullStr New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength
title_full_unstemmed New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength
title_short New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength
title_sort new advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436336/
https://www.ncbi.nlm.nih.gov/pubmed/37601044
http://dx.doi.org/10.3389/fphar.2023.1227496
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