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Recent development of polymer nanomicelles in the treatment of eye diseases

The eye, being one of the most intricate organs in the human body, hosts numerous anatomical barriers and clearance mechanisms. This highlights the importance of devising a secure and efficacious ocular medication delivery system. Over the past several decades, advancements have been made in the dev...

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Detalles Bibliográficos
Autores principales: Cai, Ruijun, Zhang, Ling, Chi, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436511/
https://www.ncbi.nlm.nih.gov/pubmed/37600322
http://dx.doi.org/10.3389/fbioe.2023.1246974
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author Cai, Ruijun
Zhang, Ling
Chi, Hao
author_facet Cai, Ruijun
Zhang, Ling
Chi, Hao
author_sort Cai, Ruijun
collection PubMed
description The eye, being one of the most intricate organs in the human body, hosts numerous anatomical barriers and clearance mechanisms. This highlights the importance of devising a secure and efficacious ocular medication delivery system. Over the past several decades, advancements have been made in the development of a nano-delivery platform based on polymeric micelles. These advancements encompass diverse innovations such as poloxamer, chitosan, hydrogel-encapsulated micelles, and contact lenses embedded with micelles. Such technological evolutions allow for sustained medication retention and facilitate enhanced permeation within the eye, thereby standing as the avant-garde in ocular medication technology. This review provides a comprehensive consolidation of ocular medications predicated on polymer nanomicelles from 2014 to 2023. Additionally, it explores the challenges they pose in clinical applications, a discussion intended to aid the design of future clinical research concerning ocular medication delivery formulations.
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spelling pubmed-104365112023-08-19 Recent development of polymer nanomicelles in the treatment of eye diseases Cai, Ruijun Zhang, Ling Chi, Hao Front Bioeng Biotechnol Bioengineering and Biotechnology The eye, being one of the most intricate organs in the human body, hosts numerous anatomical barriers and clearance mechanisms. This highlights the importance of devising a secure and efficacious ocular medication delivery system. Over the past several decades, advancements have been made in the development of a nano-delivery platform based on polymeric micelles. These advancements encompass diverse innovations such as poloxamer, chitosan, hydrogel-encapsulated micelles, and contact lenses embedded with micelles. Such technological evolutions allow for sustained medication retention and facilitate enhanced permeation within the eye, thereby standing as the avant-garde in ocular medication technology. This review provides a comprehensive consolidation of ocular medications predicated on polymer nanomicelles from 2014 to 2023. Additionally, it explores the challenges they pose in clinical applications, a discussion intended to aid the design of future clinical research concerning ocular medication delivery formulations. Frontiers Media S.A. 2023-08-04 /pmc/articles/PMC10436511/ /pubmed/37600322 http://dx.doi.org/10.3389/fbioe.2023.1246974 Text en Copyright © 2023 Cai, Zhang and Chi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Cai, Ruijun
Zhang, Ling
Chi, Hao
Recent development of polymer nanomicelles in the treatment of eye diseases
title Recent development of polymer nanomicelles in the treatment of eye diseases
title_full Recent development of polymer nanomicelles in the treatment of eye diseases
title_fullStr Recent development of polymer nanomicelles in the treatment of eye diseases
title_full_unstemmed Recent development of polymer nanomicelles in the treatment of eye diseases
title_short Recent development of polymer nanomicelles in the treatment of eye diseases
title_sort recent development of polymer nanomicelles in the treatment of eye diseases
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436511/
https://www.ncbi.nlm.nih.gov/pubmed/37600322
http://dx.doi.org/10.3389/fbioe.2023.1246974
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