Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium

INTRODUCTION: Cryptosporidiosis is a leading cause of diarrheal-associated morbidity and mortality, predominantly affecting children under 5 years old in low-and-middle-income countries. There is no effective treatment and no vaccine. New therapeutics are emerging from drug discovery efforts. It is...

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Detalles Bibliográficos
Autores principales: Hanna, Jack C., Corpas-Lopez, Victor, Seizova, Simona, Colon, Beatrice L., Bacchetti, Ross, Hall, Grant M. J., Sands, Emma M., Robinson, Lee, Baragaña, Beatriz, Wyllie, Susan, Pawlowic, Mattie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436570/
https://www.ncbi.nlm.nih.gov/pubmed/37600947
http://dx.doi.org/10.3389/fcimb.2023.1236814

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