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Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer
BACKGROUND: Magnetic resonance-guided adaptive radiotherapy (MRgART) treatment sessions at MR-Linac are time-consuming and changes in organs at risk volumes can impact the treatment dosimetry. This study aims to evaluate the feasibility to control bladder filling during the rectum MRgART online sess...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436664/ https://www.ncbi.nlm.nih.gov/pubmed/37592338 http://dx.doi.org/10.1186/s13014-023-02315-3 |
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author | Feng, Xi Tang, Bin Yao, Xinghong Liu, Min Liao, Xiongfei Yuan, Ke Peng, Qian Orlandini, Lucia Clara |
author_facet | Feng, Xi Tang, Bin Yao, Xinghong Liu, Min Liao, Xiongfei Yuan, Ke Peng, Qian Orlandini, Lucia Clara |
author_sort | Feng, Xi |
collection | PubMed |
description | BACKGROUND: Magnetic resonance-guided adaptive radiotherapy (MRgART) treatment sessions at MR-Linac are time-consuming and changes in organs at risk volumes can impact the treatment dosimetry. This study aims to evaluate the feasibility to control bladder filling during the rectum MRgART online session and its effectiveness on plan dosimetry. METHODS: A total of 109 online adaptive sessions of 24 rectum cancer patients treated at Unity 1.5 T MR-Linac with a short course radiotherapy (25 Gy, 5 Gy × 5) for whom the adaptive plan was optimized and recalculated online based on the daily magnetic resonance imaging (MRI) were analysed. Patients were fitted with a bladder catheter to control bladder filling; the bladder is emptied and then partially filled with a known amount of saline at the beginning and end of the online session. A first MRI ([Formula: see text] ) acquired at the beginning of the session was used for plan adaptation and the second ([Formula: see text] ) was acquired while approving the adapted plan and rigidly registered with the first to ensure the appropriateness of the isodoses on the ongoing delivery treatment. For each fraction, the time interval between the two MRIs and potential bladder changes were assessed with independent metrics, and the impact on the plan dosimetry was evaluated by comparing target and organs at risk dose volume histogram cut-off points of the plan adapted on [Formula: see text] and recalculated on [Formula: see text] . RESULTS: Median bladder volume variations, DSC, and HD of 8.17%, 0.922, and 2.92 mm were registered within a median time of 38 min between [Formula: see text] and [Formula: see text] ; dosimetric differences < 0.65% were registered for target coverage, and < 0.5% for bladder, small bowel and femoral heads constraints, with a p value > 0.05. CONCLUSION: The use of a bladder filling control procedure can help ensure the dosimetric accuracy of the online adapted treatment delivered. |
format | Online Article Text |
id | pubmed-10436664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104366642023-08-19 Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer Feng, Xi Tang, Bin Yao, Xinghong Liu, Min Liao, Xiongfei Yuan, Ke Peng, Qian Orlandini, Lucia Clara Radiat Oncol Research BACKGROUND: Magnetic resonance-guided adaptive radiotherapy (MRgART) treatment sessions at MR-Linac are time-consuming and changes in organs at risk volumes can impact the treatment dosimetry. This study aims to evaluate the feasibility to control bladder filling during the rectum MRgART online session and its effectiveness on plan dosimetry. METHODS: A total of 109 online adaptive sessions of 24 rectum cancer patients treated at Unity 1.5 T MR-Linac with a short course radiotherapy (25 Gy, 5 Gy × 5) for whom the adaptive plan was optimized and recalculated online based on the daily magnetic resonance imaging (MRI) were analysed. Patients were fitted with a bladder catheter to control bladder filling; the bladder is emptied and then partially filled with a known amount of saline at the beginning and end of the online session. A first MRI ([Formula: see text] ) acquired at the beginning of the session was used for plan adaptation and the second ([Formula: see text] ) was acquired while approving the adapted plan and rigidly registered with the first to ensure the appropriateness of the isodoses on the ongoing delivery treatment. For each fraction, the time interval between the two MRIs and potential bladder changes were assessed with independent metrics, and the impact on the plan dosimetry was evaluated by comparing target and organs at risk dose volume histogram cut-off points of the plan adapted on [Formula: see text] and recalculated on [Formula: see text] . RESULTS: Median bladder volume variations, DSC, and HD of 8.17%, 0.922, and 2.92 mm were registered within a median time of 38 min between [Formula: see text] and [Formula: see text] ; dosimetric differences < 0.65% were registered for target coverage, and < 0.5% for bladder, small bowel and femoral heads constraints, with a p value > 0.05. CONCLUSION: The use of a bladder filling control procedure can help ensure the dosimetric accuracy of the online adapted treatment delivered. BioMed Central 2023-08-17 /pmc/articles/PMC10436664/ /pubmed/37592338 http://dx.doi.org/10.1186/s13014-023-02315-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Feng, Xi Tang, Bin Yao, Xinghong Liu, Min Liao, Xiongfei Yuan, Ke Peng, Qian Orlandini, Lucia Clara Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer |
title | Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer |
title_full | Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer |
title_fullStr | Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer |
title_full_unstemmed | Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer |
title_short | Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer |
title_sort | effectiveness of bladder filling control during online mr-guided adaptive radiotherapy for rectal cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436664/ https://www.ncbi.nlm.nih.gov/pubmed/37592338 http://dx.doi.org/10.1186/s13014-023-02315-3 |
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