Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors

Despite being considered druggable and attractive therapeutic targets, most of the solute carrier (SLC) membrane transporters remain pharmacologically underexploited. One of the reasons for this is a lack of reliable chemical screening assays, made difficult by functional redundancies among SLCs. In...

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Detalles Bibliográficos
Autores principales: Dvorak, Vojtech, Casiraghi, Andrea, Colas, Claire, Koren, Anna, Tomek, Tatjana, Offensperger, Fabian, Rukavina, Andrea, Tin, Gary, Hahn, Elisa, Dobner, Sarah, Frommelt, Fabian, Boeszoermenyi, Andras, Bernada, Viktoriia, Hannich, J. Thomas, Ecker, Gerhard F., Winter, Georg E., Kubicek, Stefan, Superti-Furga, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10437005/
https://www.ncbi.nlm.nih.gov/pubmed/37516113
http://dx.doi.org/10.1016/j.chembiol.2023.06.029

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