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Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study

BACKGROUND: Patients with refractory symptoms of severe diseases frequently experience anxiety, depression, and an altered health-related quality of life (HRQOL). Some publications have described the beneficial effect of ozone therapy on several symptoms of this kind of patient. The aim of this stud...

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Autores principales: Clavo, Bernardino, Cánovas-Molina, Angeles, Díaz-Garrido, Juan A., Cañas, Silvia, Ramallo-Fariña, Yolanda, Laffite, Horus, Federico, Mario, Rodríguez-Abreu, Delvys, Galván, Saray, García-Lourve, Carla, González-Beltrán, Damián, Caramés, Miguel A., Hernández-Fleta, Jose L., Serrano-Aguilar, Pedro, Rodríguez-Esparragón, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10437070/
https://www.ncbi.nlm.nih.gov/pubmed/37599784
http://dx.doi.org/10.3389/fpsyg.2023.1176204
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author Clavo, Bernardino
Cánovas-Molina, Angeles
Díaz-Garrido, Juan A.
Cañas, Silvia
Ramallo-Fariña, Yolanda
Laffite, Horus
Federico, Mario
Rodríguez-Abreu, Delvys
Galván, Saray
García-Lourve, Carla
González-Beltrán, Damián
Caramés, Miguel A.
Hernández-Fleta, Jose L.
Serrano-Aguilar, Pedro
Rodríguez-Esparragón, Francisco
author_facet Clavo, Bernardino
Cánovas-Molina, Angeles
Díaz-Garrido, Juan A.
Cañas, Silvia
Ramallo-Fariña, Yolanda
Laffite, Horus
Federico, Mario
Rodríguez-Abreu, Delvys
Galván, Saray
García-Lourve, Carla
González-Beltrán, Damián
Caramés, Miguel A.
Hernández-Fleta, Jose L.
Serrano-Aguilar, Pedro
Rodríguez-Esparragón, Francisco
author_sort Clavo, Bernardino
collection PubMed
description BACKGROUND: Patients with refractory symptoms of severe diseases frequently experience anxiety, depression, and an altered health-related quality of life (HRQOL). Some publications have described the beneficial effect of ozone therapy on several symptoms of this kind of patient. The aim of this study was to preliminarily evaluate, in patients treated because of refractory symptoms of cancer treatment and advanced nononcologic diseases, if ozone therapy has an additional impact on self-reported anxiety and depression. METHODS: Before and after ozone treatment, we assessed (i) anxiety and depression according to the Hospital Anxiety and Depression Scale (HADS); (ii) the HRQOL (according to the EQ-5D-5L questionnaire), which includes a dimension on anxiety and depression and a visual analog scale (VAS) measuring self-perceived general health. RESULTS: Before ozone therapy, 56% of patients were on anxiolytic and/or antidepressant treatment. Before and after ozone therapy, the anxiety and depression HADS subscales (i) significantly correlated with the anxiety/depression dimension of the EQ-5D-5L questionnaire and (ii) inversely correlated with the health status as measured by the VAS. After ozone therapy, we found a significant improvement in anxiety and depression measured by both the (i) HADS subscales and (ii) EQ-5D-5L questionnaire. CONCLUSION: The addition of ozone therapy for patients with refractory symptoms of cancer treatment and advanced chronic nononcologic diseases can decrease anxiety and depression severity levels. Additional, more focused studies are ongoing to provide the needed explanatory information for this finding.
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spelling pubmed-104370702023-08-19 Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study Clavo, Bernardino Cánovas-Molina, Angeles Díaz-Garrido, Juan A. Cañas, Silvia Ramallo-Fariña, Yolanda Laffite, Horus Federico, Mario Rodríguez-Abreu, Delvys Galván, Saray García-Lourve, Carla González-Beltrán, Damián Caramés, Miguel A. Hernández-Fleta, Jose L. Serrano-Aguilar, Pedro Rodríguez-Esparragón, Francisco Front Psychol Psychology BACKGROUND: Patients with refractory symptoms of severe diseases frequently experience anxiety, depression, and an altered health-related quality of life (HRQOL). Some publications have described the beneficial effect of ozone therapy on several symptoms of this kind of patient. The aim of this study was to preliminarily evaluate, in patients treated because of refractory symptoms of cancer treatment and advanced nononcologic diseases, if ozone therapy has an additional impact on self-reported anxiety and depression. METHODS: Before and after ozone treatment, we assessed (i) anxiety and depression according to the Hospital Anxiety and Depression Scale (HADS); (ii) the HRQOL (according to the EQ-5D-5L questionnaire), which includes a dimension on anxiety and depression and a visual analog scale (VAS) measuring self-perceived general health. RESULTS: Before ozone therapy, 56% of patients were on anxiolytic and/or antidepressant treatment. Before and after ozone therapy, the anxiety and depression HADS subscales (i) significantly correlated with the anxiety/depression dimension of the EQ-5D-5L questionnaire and (ii) inversely correlated with the health status as measured by the VAS. After ozone therapy, we found a significant improvement in anxiety and depression measured by both the (i) HADS subscales and (ii) EQ-5D-5L questionnaire. CONCLUSION: The addition of ozone therapy for patients with refractory symptoms of cancer treatment and advanced chronic nononcologic diseases can decrease anxiety and depression severity levels. Additional, more focused studies are ongoing to provide the needed explanatory information for this finding. Frontiers Media S.A. 2023-08-04 /pmc/articles/PMC10437070/ /pubmed/37599784 http://dx.doi.org/10.3389/fpsyg.2023.1176204 Text en Copyright © 2023 Clavo, Cánovas-Molina, Díaz-Garrido, Cañas, Ramallo-Fariña, Laffite, Federico, Rodríguez-Abreu, Galván, García-Lourve, González-Beltrán, Caramés, Hernández-Fleta, Serrano-Aguilar and Rodríguez-Esparragón. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Clavo, Bernardino
Cánovas-Molina, Angeles
Díaz-Garrido, Juan A.
Cañas, Silvia
Ramallo-Fariña, Yolanda
Laffite, Horus
Federico, Mario
Rodríguez-Abreu, Delvys
Galván, Saray
García-Lourve, Carla
González-Beltrán, Damián
Caramés, Miguel A.
Hernández-Fleta, Jose L.
Serrano-Aguilar, Pedro
Rodríguez-Esparragón, Francisco
Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
title Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
title_full Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
title_fullStr Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
title_full_unstemmed Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
title_short Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
title_sort effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10437070/
https://www.ncbi.nlm.nih.gov/pubmed/37599784
http://dx.doi.org/10.3389/fpsyg.2023.1176204
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