Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses

Astroviruses (AstVs) can cause of severe infection of the central nervous system (CNS) in immunocompromised individuals. Here, we identified a human AstV of the VA1 genotype, HAstV-NIH, as the cause of fatal encephalitis in an immunocompromised adult. We investigated the cells targeted by AstV, neur...

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Detalles Bibliográficos
Autores principales: Maximova, Olga A., Weller, Melodie L., Krogmann, Tammy, Sturdevant, Daniel E., Ricklefs, Stacy, Virtaneva, Kimmo, Martens, Craig, Wollenberg, Kurt, Minai, Mahnaz, Moore, Ian N., Sauter, Craig S., Barker, Juliet N., Lipkin, W. Ian, Seilhean, Danielle, Nath, Avindra, Cohen, Jeffrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438012/
https://www.ncbi.nlm.nih.gov/pubmed/37595007
http://dx.doi.org/10.1371/journal.ppat.1011544

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