FAN1 removes triplet repeat extrusions via a PCNA- and RFC-dependent mechanism

Human genome-wide association studies have identified FAN1 and several DNA mismatch repair (MMR) genes as modifiers of Huntington’s disease age of onset. In animal models, FAN1 prevents somatic expansion of CAG triplet repeats, whereas MMR proteins promote this process. To understand the molecular b...

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Detalles Bibliográficos
Autores principales: Phadte, Ashutosh S., Bhatia, Mayuri, Ebert, Hope, Abdullah, Haaris, Elrazaq, Essam Abed, Komolov, Konstantin E., Pluciennik, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438374/
https://www.ncbi.nlm.nih.gov/pubmed/37549289
http://dx.doi.org/10.1073/pnas.2302103120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438374/
https://www.ncbi.nlm.nih.gov/pubmed/37549289
http://dx.doi.org/10.1073/pnas.2302103120

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