Cargando…
FAN1 removes triplet repeat extrusions via a PCNA- and RFC-dependent mechanism
Human genome-wide association studies have identified FAN1 and several DNA mismatch repair (MMR) genes as modifiers of Huntington’s disease age of onset. In animal models, FAN1 prevents somatic expansion of CAG triplet repeats, whereas MMR proteins promote this process. To understand the molecular b...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438374/ https://www.ncbi.nlm.nih.gov/pubmed/37549289 http://dx.doi.org/10.1073/pnas.2302103120 |