Using evolutionary constraint to define novel candidate driver genes in medulloblastoma

Current knowledge of cancer genomics remains biased against noncoding mutations. To systematically search for regulatory noncoding mutations, we assessed mutations in conserved positions in the genome under the assumption that these are more likely to be functional than mutations in positions with l...

Descripción completa

Detalles Bibliográficos
Autores principales: Roy, Ananya, Sakthikumar, Sharadha, Kozyrev, Sergey V., Nordin, Jessika, Pensch, Raphaela, Mäkeläinen, Suvi, Pettersson, Mats, Karlsson, Elinor K., Lindblad-Toh, Kerstin, Forsberg-Nilsson, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438395/
https://www.ncbi.nlm.nih.gov/pubmed/37549291
http://dx.doi.org/10.1073/pnas.2300984120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438395/
https://www.ncbi.nlm.nih.gov/pubmed/37549291
http://dx.doi.org/10.1073/pnas.2300984120

Ejemplares similares