Cargando…

Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response

BACKGROUND: Intervertebral disc degeneration (IDD) is a major cause of lower back pain (LBP), in which inflammatory is frequently involved. Amygdalin (AMD) is a naturally occurring compound that exerts anti-fibrotic, anti-inflammatory, analgesic, and immunomodulatory effects in various diseases. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Qinghe, Sun, Qi, Xu, Huihui, Chen, Jiali, Ling, Houfu, Ge, Qinwen, Zou, Kaiao, Wang, Xu, Jin, Hongting, Li, Ju, Jin, Minwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438437/ https://www.ncbi.nlm.nih.gov/pubmed/37600226 http://dx.doi.org/10.2147/JIR.S415527

Ejemplares similares

Characteristics of Stem Cells Derived from the Degenerated Human Intervertebral Disc Cartilage Endplate
por: Liu, Lan-Tao, et al.
Publicado: (2011)

Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9
por: Jiang, Chao, et al.
Publicado: (2019)

Col9a2 gene deletion accelerates the degeneration of intervertebral discs
por: Xu, Huihui, et al.
Publicado: (2022)

Osteoking Decelerates Cartilage Degeneration in DMM-Induced Osteoarthritic Mice Model Through TGF-β/smad-dependent Manner
por: Ling, Houfu, et al.
Publicado: (2021)

Degenerative Nucleus Pulposus Cells Derived Exosomes Promoted Cartilage Endplate Cells Apoptosis and Aggravated Intervertebral Disc Degeneration
por: Feng, Xiaofei, et al.
Publicado: (2022)

The correlation between microvessel pathological changes of the endplate and degeneration of the intervertebral disc in diabetic rats
por: CHEN, SEN, et al.
Publicado: (2013)

Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice
por: Xiao, Zhi-feng, et al.
Publicado: (2018)

The correlation between microvessel pathological changes of the endplate and degeneration of the intervertebral disc in diabetic rats
por: Chen, Sen, et al.
Publicado: (2020)

The role of endplate injury in intervertebral disc degeneration after vertebral augmentation in OVCF patients
por: Li, Yongchao, et al.
Publicado: (2023)

Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration
por: Luo, Liwen, et al.
Publicado: (2021)

Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy
por: Luo, Liwen, et al.
Publicado: (2021)

The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain
por: Bonnheim, Noah B., et al.
Publicado: (2022)

Inhibition of both endplate nutritional pathways results in intervertebral disc degeneration in a goat model
por: Yin, Si, et al.
Publicado: (2019)

A systematic morphology study on the effect of high glucose on intervertebral disc endplate degeneration in mice
por: Quan, Huilin, et al.
Publicado: (2023)

The mechanism by which Naru 3 pill protects against intervertebral disc cartilage endplate degeneration based on network pharmacology and experimental verification
por: Guo, Jialin, et al.
Publicado: (2023)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

Theoretical Explorations Generate New Hypotheses About the Role of the Cartilage Endplate in Early Intervertebral Disk Degeneration
por: Ruiz Wills, Carlos, et al.
Publicado: (2018)

Effects of endplate healing morphology on intervertebral disc degeneration after pedicle screw fixation for thoracolumbar fractures
por: Su, Yunshan, et al.
Publicado: (2021)

The Mechanism and Function of miRNA in Intervertebral Disc Degeneration
por: Wang, Chenglong, et al.
Publicado: (2022)

Role of Necroptosis in Intervertebral Disc Degeneration
por: Khaleque, Md Abdul, et al.
Publicado: (2023)

Pathomechanism of intervertebral disc degeneration
por: Oichi, Takeshi, et al.
Publicado: (2020)

Treatment of Intervertebral Disc Degeneration
por: Xin, Jingguo, et al.
Publicado: (2022)

Macrophages and Intervertebral Disc Degeneration
por: Koroth, Jinsha, et al.
Publicado: (2023)

Glucocorticoid-induced activation of NOX/ROS/NF-κB signaling in MSCs contributes to the development of GONFH
por: Xu, Huihui, et al.
Publicado: (2023)

Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK‐ERK signalling pathway in vivo and in vitro
por: Han, Ying‐Chao, et al.
Publicado: (2018)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration
por: Lai, Alon, et al.
Publicado: (2023)

High Endplate Hounsfield Units Value Indicate Intervertebral Disc Degeneration Following Transforaminal Lumbar Interbody Fusion Surgery
por: Zheng, Huo‐Liang, et al.
Publicado: (2023)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
por: Sun, Zhen, et al.
Publicado: (2020)

Angiogenesis in the degeneration of the lumbar intervertebral disc
por: David, Gh, et al.
Publicado: (2010)

Intervertebral disc degeneration therapies in human
por: Richardson, Stephen M
Publicado: (2015)

Genetic factors in intervertebral disc degeneration
por: Feng, Yi, et al.
Publicado: (2016)

The Role of Adipokines in Intervertebral Disc Degeneration
por: Sharma, Anirudh
Publicado: (2018)

Molecular Mechanisms of Intervertebral Disc Degeneration
por: Rider, Sean M., et al.
Publicado: (2018)

Genetic Therapy for Intervertebral Disc Degeneration
por: Roh, Eun Ji, et al.
Publicado: (2021)

Cervical intervertebral disc degeneration and dizziness
por: Liu, Tang-Hua, et al.
Publicado: (2021)

The Proteolysis of ECM in Intervertebral Disc Degeneration
por: Liang, Huaizhen, et al.
Publicado: (2022)

The role of ferroptosis in intervertebral disc degeneration
por: Fan, Chunyang, et al.
Publicado: (2023)

Comparison of the Extent of Degeneration among the Normal Disc, Immobilized Disc, and Immobilized Disc with an Endplate Fracture
por: Choi, Wonki, et al.
Publicado: (2017)

Analysis of Correlation Between Vertebral Endplate Change and Lumbar Disc Degeneration
por: Xiao, Long, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bf0981kfrjs3inr6p1ngokht57