FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer

FOXA1, a transcription factor involved in epigenetic reprogramming, is crucial for breast cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic functions remain elusive. Here, we demonstrate that the O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) of FOXA1 p...

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Detalles Bibliográficos
Autores principales: Liu, Yajie, Yu, Kairan, Kong, Xiaotian, Zhang, Keren, Wang, Lingyan, Zhang, Nana, Chen, Qiushi, Niu, Mingshan, Li, Wenli, Zhong, Xiaomin, Wu, Sijin, Zhang, Jianing, Liu, Yubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438466/
https://www.ncbi.nlm.nih.gov/pubmed/37595040
http://dx.doi.org/10.1126/sciadv.adg7112

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