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Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model

Tumors constantly interact with their microenvironment. Here, we present data on a Notch-induced neural stem cell (NSC) tumor in Drosophila, which can be immortalized by serial transplantation in adult hosts. This tumor arises in the larva by virtue of the ability of Notch to suppress early differen...

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Autores principales: Voutyraki, Chrysanthi, Choromidis, Alexandros, Meligkounaki, Anastasia, Vlachopoulos, Nikolaos Andreas, Theodorou, Vasiliki, Grammenoudi, Sofia, Athanasiadis, Emmanouil, Monticelli, Sara, Giangrande, Angela, Delidakis, Christos, Zacharioudaki, Evanthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438840/
https://www.ncbi.nlm.nih.gov/pubmed/37549261
http://dx.doi.org/10.1073/pnas.2221601120
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author Voutyraki, Chrysanthi
Choromidis, Alexandros
Meligkounaki, Anastasia
Vlachopoulos, Nikolaos Andreas
Theodorou, Vasiliki
Grammenoudi, Sofia
Athanasiadis, Emmanouil
Monticelli, Sara
Giangrande, Angela
Delidakis, Christos
Zacharioudaki, Evanthia
author_facet Voutyraki, Chrysanthi
Choromidis, Alexandros
Meligkounaki, Anastasia
Vlachopoulos, Nikolaos Andreas
Theodorou, Vasiliki
Grammenoudi, Sofia
Athanasiadis, Emmanouil
Monticelli, Sara
Giangrande, Angela
Delidakis, Christos
Zacharioudaki, Evanthia
author_sort Voutyraki, Chrysanthi
collection PubMed
description Tumors constantly interact with their microenvironment. Here, we present data on a Notch-induced neural stem cell (NSC) tumor in Drosophila, which can be immortalized by serial transplantation in adult hosts. This tumor arises in the larva by virtue of the ability of Notch to suppress early differentiation–promoting factors in NSC progeny. Guided by transcriptome data, we have addressed both tumor-intrinsic and microenvironment-specific factors and how they contribute to tumor growth and host demise. The growth promoting factors Myc, Imp, and Insulin receptor in the tumor cells are important for tumor expansion and killing of the host. From the host’s side, hemocytes, professional phagocytic blood cells, are found associated with tumor cells. Phagocytic receptors, like NimC1, are needed in hemocytes to enable them to capture and engulf tumor cells, restricting their growth. In addition to their protective role, hemocytes may also increase the host’s morbidity by their propensity to produce damaging extracellular reactive oxygen species.
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spelling pubmed-104388402023-08-19 Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model Voutyraki, Chrysanthi Choromidis, Alexandros Meligkounaki, Anastasia Vlachopoulos, Nikolaos Andreas Theodorou, Vasiliki Grammenoudi, Sofia Athanasiadis, Emmanouil Monticelli, Sara Giangrande, Angela Delidakis, Christos Zacharioudaki, Evanthia Proc Natl Acad Sci U S A Biological Sciences Tumors constantly interact with their microenvironment. Here, we present data on a Notch-induced neural stem cell (NSC) tumor in Drosophila, which can be immortalized by serial transplantation in adult hosts. This tumor arises in the larva by virtue of the ability of Notch to suppress early differentiation–promoting factors in NSC progeny. Guided by transcriptome data, we have addressed both tumor-intrinsic and microenvironment-specific factors and how they contribute to tumor growth and host demise. The growth promoting factors Myc, Imp, and Insulin receptor in the tumor cells are important for tumor expansion and killing of the host. From the host’s side, hemocytes, professional phagocytic blood cells, are found associated with tumor cells. Phagocytic receptors, like NimC1, are needed in hemocytes to enable them to capture and engulf tumor cells, restricting their growth. In addition to their protective role, hemocytes may also increase the host’s morbidity by their propensity to produce damaging extracellular reactive oxygen species. National Academy of Sciences 2023-08-07 2023-08-15 /pmc/articles/PMC10438840/ /pubmed/37549261 http://dx.doi.org/10.1073/pnas.2221601120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biological Sciences
Voutyraki, Chrysanthi
Choromidis, Alexandros
Meligkounaki, Anastasia
Vlachopoulos, Nikolaos Andreas
Theodorou, Vasiliki
Grammenoudi, Sofia
Athanasiadis, Emmanouil
Monticelli, Sara
Giangrande, Angela
Delidakis, Christos
Zacharioudaki, Evanthia
Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model
title Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model
title_full Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model
title_fullStr Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model
title_full_unstemmed Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model
title_short Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model
title_sort growth deregulation and interaction with host hemocytes contribute to tumor progression in a drosophila brain tumor model
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438840/
https://www.ncbi.nlm.nih.gov/pubmed/37549261
http://dx.doi.org/10.1073/pnas.2221601120
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