Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis

INTRODUCTION: BAY1128688 is a selective inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), an enzyme implicated in the pathology of endometriosis and other disorders. In vivo animal studies suggested a potential therapeutic application of BAY1128688 in treating endometriosis. Early clinic...

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Detalles Bibliográficos
Autores principales: Hilpert, Jan, Groettrup-Wolfers, Esther, Kosturski, Hristiyan, Bennett, Laura, Barnes, Catriona L. K., Gude, Kerstin, Gashaw, Isabella, Reif, Stefanie, Steger-Hartmann, Thomas, Scheerans, Christian, Solms, Alexander, Rottmann, Antje, Mao, Guangping, Chapron, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439066/
https://www.ncbi.nlm.nih.gov/pubmed/37422772
http://dx.doi.org/10.1007/s40268-023-00427-5

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