The net electrostatic potential and hydration of ABCG2 affect substrate transport

ABCG2 is a medically important ATP-binding cassette transporter with crucial roles in the absorption and distribution of chemically-diverse toxins and drugs, reducing the cellular accumulation of chemotherapeutic drugs to facilitate multidrug resistance in cancer. ABCG2’s capacity to transport both...

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Detalles Bibliográficos
Autores principales: Gose, Tomoka, Aitken, Heather M., Wang, Yao, Lynch, John, Rampersaud, Evadnie, Fukuda, Yu, Wills, Medb, Baril, Stefanie A., Ford, Robert C., Shelat, Anang, Mara, Megan L. O’, Schuetz, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439158/
https://www.ncbi.nlm.nih.gov/pubmed/37596258
http://dx.doi.org/10.1038/s41467-023-40610-5

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