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A matched case-control study on the effectiveness of extracorporeal cytokine adsorption in critically ill patients
Extracorporeal cytokine adsorption aims to reduce cytokine levels in critically ill patients. However, little convincing data exist to support its widespread use. This retrospective study compared interleukin-6 (IL-6) levels in patients treated with or without cytokine adsorber (CytoSorb®). Intensiv...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439174/ https://www.ncbi.nlm.nih.gov/pubmed/37596304 http://dx.doi.org/10.1038/s41598-023-40719-z |
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author | Jerman, Alexander Gubenšek, Jakob Berden, Jernej Peršič, Vanja |
author_facet | Jerman, Alexander Gubenšek, Jakob Berden, Jernej Peršič, Vanja |
author_sort | Jerman, Alexander |
collection | PubMed |
description | Extracorporeal cytokine adsorption aims to reduce cytokine levels in critically ill patients. However, little convincing data exist to support its widespread use. This retrospective study compared interleukin-6 (IL-6) levels in patients treated with or without cytokine adsorber (CytoSorb®). Intensive care patients between Jan 2017 and Dec 2021 who had at least two IL-6 measurements were included. They were divided into an adsorber group and a standard of care group. We screened 3865 patients and included 52 patients in the adsorber group and 94 patients in the standard of care group. Matching was performed and the groups were compared regarding IL-6, lactate, CRP, procalcitonin, vasopressor requirement, and mortality rate. After matching, there were 21 patients in each group. Patients had similar age, ECMO and renal replacement therapy use, baseline noradrenaline requirement, serum lactate, pH, CRP, and IL-6 levels. There were no significant differences in the time course of IL-6, lactate, CRP, procalcitonin and noradrenaline requirement between groups. Two-day and ICU mortality and Kaplan-Meier estimated survival were also comparable. In this matched case-control study no difference in IL-6, inflammatory parameters, noradrenaline requirement or mortality was observed between patients treated with adsorber or standard of care. |
format | Online Article Text |
id | pubmed-10439174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104391742023-08-20 A matched case-control study on the effectiveness of extracorporeal cytokine adsorption in critically ill patients Jerman, Alexander Gubenšek, Jakob Berden, Jernej Peršič, Vanja Sci Rep Article Extracorporeal cytokine adsorption aims to reduce cytokine levels in critically ill patients. However, little convincing data exist to support its widespread use. This retrospective study compared interleukin-6 (IL-6) levels in patients treated with or without cytokine adsorber (CytoSorb®). Intensive care patients between Jan 2017 and Dec 2021 who had at least two IL-6 measurements were included. They were divided into an adsorber group and a standard of care group. We screened 3865 patients and included 52 patients in the adsorber group and 94 patients in the standard of care group. Matching was performed and the groups were compared regarding IL-6, lactate, CRP, procalcitonin, vasopressor requirement, and mortality rate. After matching, there were 21 patients in each group. Patients had similar age, ECMO and renal replacement therapy use, baseline noradrenaline requirement, serum lactate, pH, CRP, and IL-6 levels. There were no significant differences in the time course of IL-6, lactate, CRP, procalcitonin and noradrenaline requirement between groups. Two-day and ICU mortality and Kaplan-Meier estimated survival were also comparable. In this matched case-control study no difference in IL-6, inflammatory parameters, noradrenaline requirement or mortality was observed between patients treated with adsorber or standard of care. Nature Publishing Group UK 2023-08-18 /pmc/articles/PMC10439174/ /pubmed/37596304 http://dx.doi.org/10.1038/s41598-023-40719-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Jerman, Alexander Gubenšek, Jakob Berden, Jernej Peršič, Vanja A matched case-control study on the effectiveness of extracorporeal cytokine adsorption in critically ill patients |
title | A matched case-control study on the effectiveness of extracorporeal cytokine adsorption in critically ill patients |
title_full | A matched case-control study on the effectiveness of extracorporeal cytokine adsorption in critically ill patients |
title_fullStr | A matched case-control study on the effectiveness of extracorporeal cytokine adsorption in critically ill patients |
title_full_unstemmed | A matched case-control study on the effectiveness of extracorporeal cytokine adsorption in critically ill patients |
title_short | A matched case-control study on the effectiveness of extracorporeal cytokine adsorption in critically ill patients |
title_sort | matched case-control study on the effectiveness of extracorporeal cytokine adsorption in critically ill patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439174/ https://www.ncbi.nlm.nih.gov/pubmed/37596304 http://dx.doi.org/10.1038/s41598-023-40719-z |
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