Prolonged cytopenia following CD19 CAR T cell therapy is linked with bone marrow infiltration of clonally expanded IFNγ-expressing CD8 T cells

Autologous anti-CD19 chimeric antigen receptor T cell (CAR T) therapy is highly effective in relapsed/refractory large B cell lymphoma (rrLBCL) but is associated with toxicities that delay recovery. While the biological mechanisms of cytokine release syndrome and neurotoxicity have been investigated...

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Detalles Bibliográficos
Autores principales: Strati, Paolo, Li, Xubin, Deng, Qing, Marques-Piubelli, Mario L., Henderson, Jared, Watson, Grace, Deaton, Laurel, Cain, Taylor, Yang, Haopeng, Ravanmehr, Vida, Fayad, Luis E., Iyer, Swaminathan P., Nastoupil, Loretta J., Hagemeister, Frederick B., Parra, Edwin R., Saini, Neeraj, Takahashi, Koichi, Fowler, Nathan H., Westin, Jason R., Steiner, Raphael E., Nair, Ranjit, Flowers, Christopher R., Wang, Linghua, Ahmed, Sairah, Al-Atrash, Gheath, Vega, Francisco, Neelapu, Sattva S., Green, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439270/
https://www.ncbi.nlm.nih.gov/pubmed/37586321
http://dx.doi.org/10.1016/j.xcrm.2023.101158

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