Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC

The implementation of cancer immunotherapies has seen limited clinical success in head and neck squamous cell carcinoma (HNSCC). Interleukin-2 (IL-2), which modulates the survival and functionality of lymphocytes, is an attractive target for new immunotherapies but one that is limited by presence of...

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Detalles Bibliográficos
Autores principales: Gadwa, Jacob, Amann, Maria, Bickett, Thomas E., Knitz, Michael W., Darragh, Laurel B., Piper, Miles, Van Court, Benjamin, Bukkapatnam, Sanjana, Pham, Tiffany T., Wang, Xiao-Jing, Saviola, Anthony J., Deak, Laura Codarri, Umaña, Pablo, Klein, Christian, D’Alessandro, Angelo, Karam, Sana D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439274/
https://www.ncbi.nlm.nih.gov/pubmed/37586327
http://dx.doi.org/10.1016/j.xcrm.2023.101150

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