Commensal bacteria promote azathioprine therapy failure in inflammatory bowel disease via decreasing 6-mercaptopurine bioavailability

Azathioprine (AZA) therapy failure, though not the primary cause, contributes to disease relapse and progression in inflammatory bowel disease (IBD). However, the role of gut microbiota in AZA therapy failure remains poorly understood. We found a high prevalence of Blautia wexlerae in patients with...

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Detalles Bibliográficos
Autores principales: Yan, Yuqing, Wang, Zhenhua, Zhou, Yi-Lu, Gao, Ziyun, Ning, Lijun, Zhao, Ying, Xuan, Baoqin, Ma, Yanru, Tong, Tianying, Huang, Xiaowen, Hu, Muni, Fang, Jing-Yuan, Cui, Zhe, Chen, Haoyan, Hong, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439275/
https://www.ncbi.nlm.nih.gov/pubmed/37586320
http://dx.doi.org/10.1016/j.xcrm.2023.101153

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