A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8(+) T cells

Strategies to increase intratumoral concentrations of an anticancer agent are desirable to optimize its therapeutic potential when said agent is efficacious primarily within a tumor but also have significant systemic side effects. Here, we generate a bifunctional protein by fusing interleukin-10 (IL...

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Detalles Bibliográficos
Autores principales: Chang, Yao-Wen, Hsiao, Huey-Wen, Chen, Ju-Pei, Tzeng, Sheue-Fen, Tsai, Chin-Hsien, Wu, Chun-Yi, Hsieh, Hsin-Hua, Carmona, Santiago J., Andreatta, Massimo, Di Conza, Giusy, Su, Mei-Tzu, Koni, Pandelakis A., Ho, Ping-Chih, Chen, Hung-Kai, Yang, Muh-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439276/
https://www.ncbi.nlm.nih.gov/pubmed/37586318
http://dx.doi.org/10.1016/j.xcrm.2023.101154

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