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Crystal-structure determination and Hirshfeld surface analysis of two new thiophene derivatives: (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-N-(but-2-yn-1-yl)benzenesulfonamide
In the title compounds, C(22)H(16)FNO(2)S(2) (I) and C(26)H(20)FNO(2)S(2) (II), the benzothiophene rings are essentially planar with maximum deviations of 0.009 (1) and 0.001 (1) Å for the carbon and sulfur atom in compounds I and II, respectively. In I, the thiophene ring system is almost orthog...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439409/ https://www.ncbi.nlm.nih.gov/pubmed/37601405 http://dx.doi.org/10.1107/S2056989023006096 |
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author | Madhan, S. NizamMohideen, M. Pavunkumar, Vinayagam MohanaKrishnan, Arasambattu K. |
author_facet | Madhan, S. NizamMohideen, M. Pavunkumar, Vinayagam MohanaKrishnan, Arasambattu K. |
author_sort | Madhan, S. |
collection | PubMed |
description | In the title compounds, C(22)H(16)FNO(2)S(2) (I) and C(26)H(20)FNO(2)S(2) (II), the benzothiophene rings are essentially planar with maximum deviations of 0.009 (1) and 0.001 (1) Å for the carbon and sulfur atom in compounds I and II, respectively. In I, the thiophene ring system is almost orthogonal to the phenyl ring attached to the sulfonyl group, with a dihedral angle of 77.7 (1)°. In compound I, the molecular structure is stabilized by weak C—H⋯O intramolecular interactions formed by the sulfone oxygen atoms, which generate two S(5) ring motifs. In the crystal of I, N—H⋯O hydrogen bonds link the molecules into R (2) (2)(8) rings, which are connected into a C(10) chain via C—H⋯F hydrogen bonds. Intermolecular C—H⋯π interactions are also observed. In compound II, the molecules are linked via C—H⋯O and C—H⋯F hydrogen bonding, generating infinite C(11) and C(13) chains running parallel to [010]. |
format | Online Article Text |
id | pubmed-10439409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-104394092023-08-20 Crystal-structure determination and Hirshfeld surface analysis of two new thiophene derivatives: (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-N-(but-2-yn-1-yl)benzenesulfonamide Madhan, S. NizamMohideen, M. Pavunkumar, Vinayagam MohanaKrishnan, Arasambattu K. Acta Crystallogr E Crystallogr Commun Research Communications In the title compounds, C(22)H(16)FNO(2)S(2) (I) and C(26)H(20)FNO(2)S(2) (II), the benzothiophene rings are essentially planar with maximum deviations of 0.009 (1) and 0.001 (1) Å for the carbon and sulfur atom in compounds I and II, respectively. In I, the thiophene ring system is almost orthogonal to the phenyl ring attached to the sulfonyl group, with a dihedral angle of 77.7 (1)°. In compound I, the molecular structure is stabilized by weak C—H⋯O intramolecular interactions formed by the sulfone oxygen atoms, which generate two S(5) ring motifs. In the crystal of I, N—H⋯O hydrogen bonds link the molecules into R (2) (2)(8) rings, which are connected into a C(10) chain via C—H⋯F hydrogen bonds. Intermolecular C—H⋯π interactions are also observed. In compound II, the molecules are linked via C—H⋯O and C—H⋯F hydrogen bonding, generating infinite C(11) and C(13) chains running parallel to [010]. International Union of Crystallography 2023-07-21 /pmc/articles/PMC10439409/ /pubmed/37601405 http://dx.doi.org/10.1107/S2056989023006096 Text en © Madhan et al. 2023 https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Research Communications Madhan, S. NizamMohideen, M. Pavunkumar, Vinayagam MohanaKrishnan, Arasambattu K. Crystal-structure determination and Hirshfeld surface analysis of two new thiophene derivatives: (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-N-(but-2-yn-1-yl)benzenesulfonamide |
title | Crystal-structure determination and Hirshfeld surface analysis of two new thiophene derivatives: (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-N-(but-2-yn-1-yl)benzenesulfonamide |
title_full | Crystal-structure determination and Hirshfeld surface analysis of two new thiophene derivatives: (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-N-(but-2-yn-1-yl)benzenesulfonamide |
title_fullStr | Crystal-structure determination and Hirshfeld surface analysis of two new thiophene derivatives: (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-N-(but-2-yn-1-yl)benzenesulfonamide |
title_full_unstemmed | Crystal-structure determination and Hirshfeld surface analysis of two new thiophene derivatives: (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-N-(but-2-yn-1-yl)benzenesulfonamide |
title_short | Crystal-structure determination and Hirshfeld surface analysis of two new thiophene derivatives: (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (E)-N-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-N-(but-2-yn-1-yl)benzenesulfonamide |
title_sort | crystal-structure determination and hirshfeld surface analysis of two new thiophene derivatives: (e)-n-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}benzenesulfonamide and (e)-n-{2-[2-(benzo[b]thiophen-2-yl)ethenyl]-5-fluorophenyl}-n-(but-2-yn-1-yl)benzenesulfonamide |
topic | Research Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439409/ https://www.ncbi.nlm.nih.gov/pubmed/37601405 http://dx.doi.org/10.1107/S2056989023006096 |
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