Co-crystallization of N′-benzyl­idene­pyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde

The 1:1 co-crystal N′-[(2-methyl­phen­yl)methyl­idene]pyridine-4-carbohydrazide–benzoic acid (1/1), C(13)H(11)N(3)O·C(7)H(6)O(2), formed unexpectedly after autoxidation of benzaldehyde during the slow evaporation process of a solution of isoniazid in benzaldehyde. The original intent of the synthesi...

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Detalles Bibliográficos
Autores principales: Setshedi, Itumeleng B., Lemmerer, Andreas, Smith, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439410/
https://www.ncbi.nlm.nih.gov/pubmed/37601390
http://dx.doi.org/10.1107/S2056989023005698
Descripción
Sumario:The 1:1 co-crystal N′-[(2-methyl­phen­yl)methyl­idene]pyridine-4-carbohydrazide–benzoic acid (1/1), C(13)H(11)N(3)O·C(7)H(6)O(2), formed unexpectedly after autoxidation of benzaldehyde during the slow evaporation process of a solution of isoniazid in benzaldehyde. The original intent of the synthesis was to modify isoniazid with benzaldehyde and crystallize the product in order to improve efficacy against Mycobacteria species, but benzoic acid formed spontaneously and co-crystallized with the intended product, N′-benzyl­idene­pyridine-4-carbohydrazide.

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