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Co-crystallization of N′-benzylidenepyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde
The 1:1 co-crystal N′-[(2-methylphenyl)methylidene]pyridine-4-carbohydrazide–benzoic acid (1/1), C(13)H(11)N(3)O·C(7)H(6)O(2), formed unexpectedly after autoxidation of benzaldehyde during the slow evaporation process of a solution of isoniazid in benzaldehyde. The original intent of the synthesi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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International Union of Crystallography
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439410/ https://www.ncbi.nlm.nih.gov/pubmed/37601390 http://dx.doi.org/10.1107/S2056989023005698 |
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| author | Setshedi, Itumeleng B. Lemmerer, Andreas Smith, Mark G. |
| author_facet | Setshedi, Itumeleng B. Lemmerer, Andreas Smith, Mark G. |
| author_sort | Setshedi, Itumeleng B. |
| collection | PubMed |
| description | The 1:1 co-crystal N′-[(2-methylphenyl)methylidene]pyridine-4-carbohydrazide–benzoic acid (1/1), C(13)H(11)N(3)O·C(7)H(6)O(2), formed unexpectedly after autoxidation of benzaldehyde during the slow evaporation process of a solution of isoniazid in benzaldehyde. The original intent of the synthesis was to modify isoniazid with benzaldehyde and crystallize the product in order to improve efficacy against Mycobacteria species, but benzoic acid formed spontaneously and co-crystallized with the intended product, N′-benzylidenepyridine-4-carbohydrazide. |
| format | Online Article Text |
| id | pubmed-10439410 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104394102023-08-20 Co-crystallization of N′-benzylidenepyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde Setshedi, Itumeleng B. Lemmerer, Andreas Smith, Mark G. Acta Crystallogr E Crystallogr Commun Research Communications The 1:1 co-crystal N′-[(2-methylphenyl)methylidene]pyridine-4-carbohydrazide–benzoic acid (1/1), C(13)H(11)N(3)O·C(7)H(6)O(2), formed unexpectedly after autoxidation of benzaldehyde during the slow evaporation process of a solution of isoniazid in benzaldehyde. The original intent of the synthesis was to modify isoniazid with benzaldehyde and crystallize the product in order to improve efficacy against Mycobacteria species, but benzoic acid formed spontaneously and co-crystallized with the intended product, N′-benzylidenepyridine-4-carbohydrazide. International Union of Crystallography 2023-07-04 /pmc/articles/PMC10439410/ /pubmed/37601390 http://dx.doi.org/10.1107/S2056989023005698 Text en © Setshedi et al. 2023 https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Research Communications Setshedi, Itumeleng B. Lemmerer, Andreas Smith, Mark G. Co-crystallization of N′-benzylidenepyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde |
| title | Co-crystallization of N′-benzylidenepyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde |
| title_full | Co-crystallization of N′-benzylidenepyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde |
| title_fullStr | Co-crystallization of N′-benzylidenepyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde |
| title_full_unstemmed | Co-crystallization of N′-benzylidenepyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde |
| title_short | Co-crystallization of N′-benzylidenepyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde |
| title_sort | co-crystallization of n′-benzylidenepyridine-4-carbohydrazide and benzoic acid via autoxidation of benzaldehyde |
| topic | Research Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439410/ https://www.ncbi.nlm.nih.gov/pubmed/37601390 http://dx.doi.org/10.1107/S2056989023005698 |
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