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Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older
BACKGROUND: There is limited information on short- and long-term effects of venous thromboembolism (VTE) on health-related quality of life (HRQoL) in the elderly. OBJECTIVES: To assess change in generic HRQoL and disease-specific HRQoL in patients 1 year after the VTE. METHODS: The Age and Thrombosi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439441/ https://www.ncbi.nlm.nih.gov/pubmed/37601012 http://dx.doi.org/10.1016/j.rpth.2023.102144 |
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author | Wang, Huijie Klok, Frederikus A. Rosendaal, Frits R. Cushman, Mary van Hylckama Vlieg, Astrid |
author_facet | Wang, Huijie Klok, Frederikus A. Rosendaal, Frits R. Cushman, Mary van Hylckama Vlieg, Astrid |
author_sort | Wang, Huijie |
collection | PubMed |
description | BACKGROUND: There is limited information on short- and long-term effects of venous thromboembolism (VTE) on health-related quality of life (HRQoL) in the elderly. OBJECTIVES: To assess change in generic HRQoL and disease-specific HRQoL in patients 1 year after the VTE. METHODS: The Age and Thrombosis, Acquired and Genetic risk factors in the elderly (AT-AGE) study is a 2-center case-control study performed in Leiden, the Netherlands, and Vermont, United States, among individuals aged ≥70 years. We measured generic HRQoL using the 36-item Short Form Health Survey (SF-36) and disease-specific HRQoL using the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms Questionnaire (VEINES-QoL/Sym) and the Pulmonary Embolism–Specific Quality of Life Questionnaire (PEmb-QoL). All patients completed these questionnaires shortly after their VTE and 1 year later, while controls completed the 36-item Short Form Health Survey questionnaire once. Linear regression for change in quality of life scores was performed and adjusted for potential confounders. RESULTS: For the current analysis, we included patients who were visited twice (n = 316) and controls (n = 427) with HRQoL information. Mean age of patients and controls was similar (78.8 vs 75.5 years). In patients who survived at least 1 year after the VTE, generic HRQoL improved for both summary scores, but it did not reach the level of the age-matched controls: physical and mental summary scores increased by 5.6 and 5.5 points, respectively, but compared with controls, remained 8.2 and 6.4 points lower. For disease-specific HRQoL, the Pulmonary Embolism–Specific Quality of Life Questionnaire overall score decreased from 21.7% to 15.2%, indicating improved HRQoL. Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms Questionnaire scores did not change over time. CONCLUSION: Overall, the quality of life of patients with VTE was worse than that of controls after 1 year, indicating a long-term impact of VTE diagnosis in the elderly. |
format | Online Article Text |
id | pubmed-10439441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104394412023-08-20 Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older Wang, Huijie Klok, Frederikus A. Rosendaal, Frits R. Cushman, Mary van Hylckama Vlieg, Astrid Res Pract Thromb Haemost Original Article BACKGROUND: There is limited information on short- and long-term effects of venous thromboembolism (VTE) on health-related quality of life (HRQoL) in the elderly. OBJECTIVES: To assess change in generic HRQoL and disease-specific HRQoL in patients 1 year after the VTE. METHODS: The Age and Thrombosis, Acquired and Genetic risk factors in the elderly (AT-AGE) study is a 2-center case-control study performed in Leiden, the Netherlands, and Vermont, United States, among individuals aged ≥70 years. We measured generic HRQoL using the 36-item Short Form Health Survey (SF-36) and disease-specific HRQoL using the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms Questionnaire (VEINES-QoL/Sym) and the Pulmonary Embolism–Specific Quality of Life Questionnaire (PEmb-QoL). All patients completed these questionnaires shortly after their VTE and 1 year later, while controls completed the 36-item Short Form Health Survey questionnaire once. Linear regression for change in quality of life scores was performed and adjusted for potential confounders. RESULTS: For the current analysis, we included patients who were visited twice (n = 316) and controls (n = 427) with HRQoL information. Mean age of patients and controls was similar (78.8 vs 75.5 years). In patients who survived at least 1 year after the VTE, generic HRQoL improved for both summary scores, but it did not reach the level of the age-matched controls: physical and mental summary scores increased by 5.6 and 5.5 points, respectively, but compared with controls, remained 8.2 and 6.4 points lower. For disease-specific HRQoL, the Pulmonary Embolism–Specific Quality of Life Questionnaire overall score decreased from 21.7% to 15.2%, indicating improved HRQoL. Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms Questionnaire scores did not change over time. CONCLUSION: Overall, the quality of life of patients with VTE was worse than that of controls after 1 year, indicating a long-term impact of VTE diagnosis in the elderly. Elsevier 2023-06-30 /pmc/articles/PMC10439441/ /pubmed/37601012 http://dx.doi.org/10.1016/j.rpth.2023.102144 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Wang, Huijie Klok, Frederikus A. Rosendaal, Frits R. Cushman, Mary van Hylckama Vlieg, Astrid Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older |
title | Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older |
title_full | Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older |
title_fullStr | Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older |
title_full_unstemmed | Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older |
title_short | Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older |
title_sort | health-related quality of life after first venous thromboembolism in individuals aged 70 years and older |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439441/ https://www.ncbi.nlm.nih.gov/pubmed/37601012 http://dx.doi.org/10.1016/j.rpth.2023.102144 |
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