Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi

Extracellular vesicles (EVs) are a heterogeneous group of lipid membrane-enclosed compartments that contain different biomolecules and are released by almost all living cells, including fungal genera. Fungal EVs contain multiple bioactive components that perform various biological functions, such as...

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Autores principales: Ullah, Amir, Huang, Yiyi, Zhao, Kening, Hua, Yuneng, Ullah, Shafi, Rahman, Mujeeb ur, Wang, Jingyu, Wang, Qian, Hu, Xiumei, Zheng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439556/
https://www.ncbi.nlm.nih.gov/pubmed/37598156
http://dx.doi.org/10.1186/s12866-023-02945-3
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author Ullah, Amir
Huang, Yiyi
Zhao, Kening
Hua, Yuneng
Ullah, Shafi
Rahman, Mujeeb ur
Wang, Jingyu
Wang, Qian
Hu, Xiumei
Zheng, Lei
author_facet Ullah, Amir
Huang, Yiyi
Zhao, Kening
Hua, Yuneng
Ullah, Shafi
Rahman, Mujeeb ur
Wang, Jingyu
Wang, Qian
Hu, Xiumei
Zheng, Lei
author_sort Ullah, Amir
collection PubMed
description Extracellular vesicles (EVs) are a heterogeneous group of lipid membrane-enclosed compartments that contain different biomolecules and are released by almost all living cells, including fungal genera. Fungal EVs contain multiple bioactive components that perform various biological functions, such as stimulation of the host immune system, transport of virulence factors, induction of biofilm formation, and mediation of host–pathogen interactions. In this review, we summarize the current knowledge on EVs of human pathogenic fungi, mainly focusing on their biogenesis, composition, and biological effects. We also discuss the potential markers and therapeutic applications of fungal EVs.
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spelling pubmed-104395562023-08-20 Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi Ullah, Amir Huang, Yiyi Zhao, Kening Hua, Yuneng Ullah, Shafi Rahman, Mujeeb ur Wang, Jingyu Wang, Qian Hu, Xiumei Zheng, Lei BMC Microbiol Review Extracellular vesicles (EVs) are a heterogeneous group of lipid membrane-enclosed compartments that contain different biomolecules and are released by almost all living cells, including fungal genera. Fungal EVs contain multiple bioactive components that perform various biological functions, such as stimulation of the host immune system, transport of virulence factors, induction of biofilm formation, and mediation of host–pathogen interactions. In this review, we summarize the current knowledge on EVs of human pathogenic fungi, mainly focusing on their biogenesis, composition, and biological effects. We also discuss the potential markers and therapeutic applications of fungal EVs. BioMed Central 2023-08-19 /pmc/articles/PMC10439556/ /pubmed/37598156 http://dx.doi.org/10.1186/s12866-023-02945-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ullah, Amir
Huang, Yiyi
Zhao, Kening
Hua, Yuneng
Ullah, Shafi
Rahman, Mujeeb ur
Wang, Jingyu
Wang, Qian
Hu, Xiumei
Zheng, Lei
Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi
title Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi
title_full Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi
title_fullStr Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi
title_full_unstemmed Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi
title_short Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi
title_sort characteristics and potential clinical applications of the extracellular vesicles of human pathogenic fungi
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439556/
https://www.ncbi.nlm.nih.gov/pubmed/37598156
http://dx.doi.org/10.1186/s12866-023-02945-3
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