The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis

BACKGROUND: Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to degeneration. aSyn-O can induce Ca(2+) influx, over activating downstream pathways leading to PD phenotype. Calcineurin (CN), a phosphatase regulat...

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Detalles Bibliográficos
Autores principales: Sant’Anna, Ricardo, Robbs, Bruno K., de Freitas, Júlia Araújo, dos Santos, Patrícia Pires, König, Annekatrin, Outeiro, Tiago Fleming, Foguel, Debora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439599/
https://www.ncbi.nlm.nih.gov/pubmed/37596531
http://dx.doi.org/10.1186/s10020-023-00704-8

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