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Advanced brain MRI may help understand the link between migraine and multiple sclerosis

BACKGROUND: There is a clinical association between migraine and multiple sclerosis. MAIN BODY: Migraine and MS patients share similar demographics, with the highest incidence among young, female and otherwise healthy patients. The same hormonal constellations/changes trigger disease exacerbation in...

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Autores principales: Huang, Susie Y., Salomon, Marc, Eikermann-Haerter, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439604/
https://www.ncbi.nlm.nih.gov/pubmed/37596546
http://dx.doi.org/10.1186/s10194-023-01645-7
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author Huang, Susie Y.
Salomon, Marc
Eikermann-Haerter, Katharina
author_facet Huang, Susie Y.
Salomon, Marc
Eikermann-Haerter, Katharina
author_sort Huang, Susie Y.
collection PubMed
description BACKGROUND: There is a clinical association between migraine and multiple sclerosis. MAIN BODY: Migraine and MS patients share similar demographics, with the highest incidence among young, female and otherwise healthy patients. The same hormonal constellations/changes trigger disease exacerbation in both entities. Migraine prevalence is increased in MS patients, which is further enhanced by disease-modifying treatment. Clinical data show that onset of migraine typically starts years before the clinical diagnosis of MS, suggesting that there is either a unidirectional relationship with migraine predisposing to MS, and/or a “shared factor” underlying both conditions. Brain imaging studies show white matter lesions in both MS and migraine patients. Neuroinflammatory mechanisms likely play a key role, at least as a shared downstream pathway. In this review article, we provide an overview of the literature about 1) the clinical association between migraine and MS as well as 2) brain MRI studies that help us better understand the mechanistic relationship between both diseases with implications on their underlying pathophysiology. CONCLUSION: Studies suggest a migraine history predisposes patients to develop MS. Advanced brain MR imaging may shed light on shared and distinct features, while helping us better understand mechanisms underlying both disease entities.
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spelling pubmed-104396042023-08-20 Advanced brain MRI may help understand the link between migraine and multiple sclerosis Huang, Susie Y. Salomon, Marc Eikermann-Haerter, Katharina J Headache Pain Review BACKGROUND: There is a clinical association between migraine and multiple sclerosis. MAIN BODY: Migraine and MS patients share similar demographics, with the highest incidence among young, female and otherwise healthy patients. The same hormonal constellations/changes trigger disease exacerbation in both entities. Migraine prevalence is increased in MS patients, which is further enhanced by disease-modifying treatment. Clinical data show that onset of migraine typically starts years before the clinical diagnosis of MS, suggesting that there is either a unidirectional relationship with migraine predisposing to MS, and/or a “shared factor” underlying both conditions. Brain imaging studies show white matter lesions in both MS and migraine patients. Neuroinflammatory mechanisms likely play a key role, at least as a shared downstream pathway. In this review article, we provide an overview of the literature about 1) the clinical association between migraine and MS as well as 2) brain MRI studies that help us better understand the mechanistic relationship between both diseases with implications on their underlying pathophysiology. CONCLUSION: Studies suggest a migraine history predisposes patients to develop MS. Advanced brain MR imaging may shed light on shared and distinct features, while helping us better understand mechanisms underlying both disease entities. Springer Milan 2023-08-18 /pmc/articles/PMC10439604/ /pubmed/37596546 http://dx.doi.org/10.1186/s10194-023-01645-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Huang, Susie Y.
Salomon, Marc
Eikermann-Haerter, Katharina
Advanced brain MRI may help understand the link between migraine and multiple sclerosis
title Advanced brain MRI may help understand the link between migraine and multiple sclerosis
title_full Advanced brain MRI may help understand the link between migraine and multiple sclerosis
title_fullStr Advanced brain MRI may help understand the link between migraine and multiple sclerosis
title_full_unstemmed Advanced brain MRI may help understand the link between migraine and multiple sclerosis
title_short Advanced brain MRI may help understand the link between migraine and multiple sclerosis
title_sort advanced brain mri may help understand the link between migraine and multiple sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439604/
https://www.ncbi.nlm.nih.gov/pubmed/37596546
http://dx.doi.org/10.1186/s10194-023-01645-7
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