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Advanced brain MRI may help understand the link between migraine and multiple sclerosis
BACKGROUND: There is a clinical association between migraine and multiple sclerosis. MAIN BODY: Migraine and MS patients share similar demographics, with the highest incidence among young, female and otherwise healthy patients. The same hormonal constellations/changes trigger disease exacerbation in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439604/ https://www.ncbi.nlm.nih.gov/pubmed/37596546 http://dx.doi.org/10.1186/s10194-023-01645-7 |
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author | Huang, Susie Y. Salomon, Marc Eikermann-Haerter, Katharina |
author_facet | Huang, Susie Y. Salomon, Marc Eikermann-Haerter, Katharina |
author_sort | Huang, Susie Y. |
collection | PubMed |
description | BACKGROUND: There is a clinical association between migraine and multiple sclerosis. MAIN BODY: Migraine and MS patients share similar demographics, with the highest incidence among young, female and otherwise healthy patients. The same hormonal constellations/changes trigger disease exacerbation in both entities. Migraine prevalence is increased in MS patients, which is further enhanced by disease-modifying treatment. Clinical data show that onset of migraine typically starts years before the clinical diagnosis of MS, suggesting that there is either a unidirectional relationship with migraine predisposing to MS, and/or a “shared factor” underlying both conditions. Brain imaging studies show white matter lesions in both MS and migraine patients. Neuroinflammatory mechanisms likely play a key role, at least as a shared downstream pathway. In this review article, we provide an overview of the literature about 1) the clinical association between migraine and MS as well as 2) brain MRI studies that help us better understand the mechanistic relationship between both diseases with implications on their underlying pathophysiology. CONCLUSION: Studies suggest a migraine history predisposes patients to develop MS. Advanced brain MR imaging may shed light on shared and distinct features, while helping us better understand mechanisms underlying both disease entities. |
format | Online Article Text |
id | pubmed-10439604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-104396042023-08-20 Advanced brain MRI may help understand the link between migraine and multiple sclerosis Huang, Susie Y. Salomon, Marc Eikermann-Haerter, Katharina J Headache Pain Review BACKGROUND: There is a clinical association between migraine and multiple sclerosis. MAIN BODY: Migraine and MS patients share similar demographics, with the highest incidence among young, female and otherwise healthy patients. The same hormonal constellations/changes trigger disease exacerbation in both entities. Migraine prevalence is increased in MS patients, which is further enhanced by disease-modifying treatment. Clinical data show that onset of migraine typically starts years before the clinical diagnosis of MS, suggesting that there is either a unidirectional relationship with migraine predisposing to MS, and/or a “shared factor” underlying both conditions. Brain imaging studies show white matter lesions in both MS and migraine patients. Neuroinflammatory mechanisms likely play a key role, at least as a shared downstream pathway. In this review article, we provide an overview of the literature about 1) the clinical association between migraine and MS as well as 2) brain MRI studies that help us better understand the mechanistic relationship between both diseases with implications on their underlying pathophysiology. CONCLUSION: Studies suggest a migraine history predisposes patients to develop MS. Advanced brain MR imaging may shed light on shared and distinct features, while helping us better understand mechanisms underlying both disease entities. Springer Milan 2023-08-18 /pmc/articles/PMC10439604/ /pubmed/37596546 http://dx.doi.org/10.1186/s10194-023-01645-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Huang, Susie Y. Salomon, Marc Eikermann-Haerter, Katharina Advanced brain MRI may help understand the link between migraine and multiple sclerosis |
title | Advanced brain MRI may help understand the link between migraine and multiple sclerosis |
title_full | Advanced brain MRI may help understand the link between migraine and multiple sclerosis |
title_fullStr | Advanced brain MRI may help understand the link between migraine and multiple sclerosis |
title_full_unstemmed | Advanced brain MRI may help understand the link between migraine and multiple sclerosis |
title_short | Advanced brain MRI may help understand the link between migraine and multiple sclerosis |
title_sort | advanced brain mri may help understand the link between migraine and multiple sclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439604/ https://www.ncbi.nlm.nih.gov/pubmed/37596546 http://dx.doi.org/10.1186/s10194-023-01645-7 |
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